ArticleAmerican journal of physiology. Lung cellular and molecular physiology2008
Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice.
Article in American journal of physiology. Lung cellular and molecular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages.Cell discovery · 2021Article
- The bioactivity of soluble Fas ligand is modulated by key amino acids of its stalk region.PloS one · 2021Article
- Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.PLoS pathogens · 2019Article
- Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.Journal of leukocyte biology · 2018Article
- Myeloid-epithelial cross talk coordinates synthesis of the tissue-protective cytokine leukemia inhibitory factor during pneumonia.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Cytokine-Ion Channel Interactions in Pulmonary Inflammation.Frontiers in immunology · 2017Review
- Macrophage-epithelial interactions in pulmonary alveoli.Seminars in immunopathology · 2016Review
- Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Alveolar macrophage depletion increases the severity of acute inflammation following nonlethal unilateral lung contusion in mice.The journal of trauma and acute care surgery · 2014Article
- TNF-induced death signaling triggers alveolar epithelial dysfunction in acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Article
- Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.American journal of respiratory and critical care medicine · 2012Article
- Studying the mononuclear phagocyte system in the molecular age.Nature reviews. Immunology · 2011Review
- Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Fas activation in alveolar epithelial cells induces KC (CXCL1) release by a MyD88-dependent mechanism.American journal of respiratory cell and molecular biology · 2011Article
- Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis.Journal of Zhejiang University. Science. B · 2010Article
- Fas inhibition attenuates lipopolysaccharide-induced apoptosis and cytokine release of rat type II alveolar epithelial cells.Molecular biology reports · 2010Article
- Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice.Journal of virology · 2010Article
- Febrile-range hyperthermia augments lipopolysaccharide-induced lung injury by a mechanism of enhanced alveolar epithelial apoptosis.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury.Critical care medicine · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Activation of the Fas/Fas ligand (FasL) system in the lungs results in a form of injury characterized by alveolar epithelial apoptosis and neutrophilic inflammation. Studies in vitro show that Fas activation induces apoptosis in alveolar epithelial cells and cytokine production in alveolar macrophages. The main goal of this study was to determine the contribution of alveolar macrophages to Fas-induced lung inflammation in mice, by depleting alveolar macrophages using clodronate-containing liposomes. Liposomes containing clodronate or PBS were instilled by intratracheal instillation. After 24 h, the mice received intratracheal instillations of the Fas-activating monoclonal antibody Jo2 or an isotype control antibody and were studied 18 h later. The Jo2 MAb induced increases in bronchoalveolar lavage fluid (BALF) total neutrophils, lung caspase-3 activity, and BALF total protein and worsened histological lung injury in the macrophage-depleted mice. Studies in vitro showed that Fas activation induced the release of the cytokine KC in a mouse lung epithelial cell line, MLE-12. These results suggest that the lung inflammatory response to Fas activation is not primarily dependent on resident alveolar macrophages and may instead depend on cytokine release by alveolar epithelial cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.