ArticleJournal of bacteriology2008
Replacement of adenylate cyclase toxin in a lineage of Bordetella bronchiseptica.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Genetic diversity ofFrontiers in microbiology · 2025Article
- Comparative analysis of antimicrobial resistance and genetic diversity ofFrontiers in microbiology · 2024Article
- A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies.Nature communications · 2022Article
- Development of macrolide resistance in Bordetella bronchiseptica is associated with the loss of virulence.The Journal of antimicrobial chemotherapy · 2018Article
- Blood or Serum Exposure Induce Global Transcriptional Changes, Altered Antigenic Profile, and Increased Cytotoxicity by Classical Bordetellae.Frontiers in microbiology · 2018Article
- Bordetella Adenylate Cyclase-Hemolysin Toxins.Toxins · 2017Review
- Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella species.BMC genomics · 2016Article
- Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22.Veterinary microbiology · 2016Article
- Diversity of secretion systems associated with virulence characteristics of the classical bordetellae.Microbiology (Reading, England) · 2015Article
- Novel, host-restricted genotypes of Bordetella bronchiseptica associated with phocine respiratory tract isolates.Microbiology (Reading, England) · 2015Article
- Comparative analyses of a cystic fibrosis isolate of Bordetella bronchiseptica reveal differences in important pathogenic phenotypes.Infection and immunity · 2014Article
- Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens.BMC genomics · 2012Article
- Phenotypic and genomic analysis of hypervirulent human-associated Bordetella bronchiseptica.BMC microbiology · 2012Article
- Bordetella bronchiseptica in a paediatric cystic fibrosis patient: possible transmission from a household cat.Zoonoses and public health · 2012Article
- Article
- A Type VI secretion system encoding locus is required for Bordetella bronchiseptica immunomodulation and persistence in vivo.PloS one · 2012Article
- Identification of a CO2 responsive regulon in Bordetella.PloS one · 2012Article
- Bordetella petrii infection with long-lasting persistence in human.Emerging infectious diseases · 2011Article
- Microarray and functional analysis of growth phase-dependent gene regulation in Bordetella bronchiseptica.Infection and immunity · 2009Article
- Role of the type III secretion system in a hypervirulent lineage of Bordetella bronchiseptica.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Bordetella bronchiseptica is a gram-negative respiratory pathogen that infects a wide range of hosts and causes a diverse spectrum of disease. This diversity is likely affected by multiple factors, such as host immune status, polymicrobial infection, and strain diversity. In a murine model of infection, we found that the virulence of B. bronchiseptica strains, as measured by the mean lethal dose, varied widely. Strain 253 was less virulent than the typically studied strain, RB50. Transcriptome analysis showed that cyaA, the gene encoding adenylate cyclase toxin (CyaA), was the most downregulated transcript identified in strain 253 compared to that in strain RB50. Comparative genomic hybridization and genome sequencing of strain 253 revealed that the cya locus, which encodes, activates, and secretes CyaA, was replaced by an operon (ptp) predicted to encode peptide transport proteins. Other B. bronchiseptica strains from the same phylogenetic lineage as that of strain 253 also lacked the cya locus, contained the ptp genes, and were less virulent than strain RB50. Although the loss of CyaA would be expected to be counterselected since it is conserved among the classical bordetellae and believed to be important to their success, our data indicate that the loss of this toxin and the gain of the ptp genes occurred in an ancestral strain that then expanded into a lineage. This suggests that there may be ecological niches in which CyaA is not critical for the success of B. bronchiseptica.
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