ArticleJournal of bacteriology2008
Characterization of lipooligosaccharide-biosynthetic loci of Campylobacter jejuni reveals new lipooligosaccharide classes: evidence of mosaic organizations.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Virulence and Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026Review
- Genomic variability of lipooligosaccharide biosynthesis locus and sequence type amongMicrobiology spectrum · 2025Article
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- Pathogenicity and virulence ofVirulence · 2024Review
- Emerging Sialylated Class R Lipooligosaccharides inChina CDC weekly · 2024Article
- Phocaeicola acetigenes sp. nov., producing acetic acid and iso-butyric acid, isolated faeces from a healthy human.Antonie van Leeuwenhoek · 2024Article
- Shotgun metagenomics of fecal samples from children in Peru reveals frequent complex co-infections with multiple Campylobacter species.PLoS neglected tropical diseases · 2022Article
- Zoonotic Transmission ofFrontiers in microbiology · 2022Article
- Molecular and in silico typing of the lipooligosaccharide biosynthesis gene cluster in Campylobacter jejuni and Campylobacter coli.PloS one · 2022Article
- Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans.Communications biology · 2021Article
- Axonal variants of Guillain-Barré syndrome: an update.Journal of neurology · 2021Review
- Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations ofFrontiers in microbiology · 2021Article
- Phase Variation During Host Colonization and Invasion byFrontiers in microbiology · 2021Review
- Article
- Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon.PLoS neglected tropical diseases · 2020Article
- Differential Distribution of theMicroorganisms · 2020Article
- RevisitingFrontiers in cellular and infection microbiology · 2020Review
- An Updated Classification System and Review of the Lipooligosaccharide Biosynthesis Gene Locus inFrontiers in microbiology · 2020Review
- Distribution of genes related to Type 6 secretion system and lipooligosaccharide that induced ganglioside mimicry amongGut pathogens · 2020Article
- Domestication of Campylobacter jejuni NCTC 11168.Microbial genomics · 2019Article
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Authors and funding
5 authors.
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Abstract
The lipooligosaccharide (LOS) biosynthesis region is one of the more variable genomic regions between strains of Campylobacter jejuni. Indeed, eight classes of LOS biosynthesis loci have been established previously based on gene content and organization. In this study, we characterize additional classes of LOS biosynthesis loci and analyze various mechanisms that result in changes to LOS structures. To gain further insights into the genomic diversity of C. jejuni LOS biosynthesis region, we sequenced the LOS biosynthesis loci of 15 strains that possessed gene content that was distinct from the eight classes. This analysis identified 11 new classes of LOS loci that exhibited examples of deletions and insertions of genes and cassettes of genes found in other LOS classes or capsular biosynthesis loci leading to mosaic LOS loci. The sequence analysis also revealed both missense mutations leading to "allelic" glycosyltransferases and phase-variable and non-phase-variable gene inactivation by the deletion or insertion of bases. Specifically, we demonstrated that gene inactivation is an important mechanism for altering the LOS structures of strains possessing the same class of LOS biosynthesis locus. Together, these observations suggest that LOS biosynthesis region is a hotspot for genetic exchange and variability, often leading to changes in the LOS produced.
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