ArticleNucleic acids research2008
Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 43 citations in OpenAlex.
- The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation.Developmental cell · 2024Article
- Mapping cis-regulatory elements in the midgestation mouse placenta.Scientific reports · 2021Article
- Evidence of widespread, independent sequence signature for transcription factor cobinding.Genome research · 2021Article
- NURR1 activation in skeletal muscle controls systemic energy homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Combined analysis of dissimilar promoter accessibility and gene expression profiles identifies tissue-specific genes and actively repressed networks.Epigenetics & chromatin · 2019Article
- Genetic determinants and epigenetic effects of pioneer-factor occupancy.Nature genetics · 2018Article
- A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism.Genes & development · 2016Article
- Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein.The Journal of biological chemistry · 2016Article
- Changes in the enhancer landscape during early placental development uncover a trophoblast invasion gene-enhancer network.Placenta · 2016Article
- CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells.Molecular metabolism · 2014Article
- Minireview: pioneer transcription factors in cell fate specification.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver.BMC genomics · 2013Article
- Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.PLoS genetics · 2013Article
- Identification of co-occurring transcription factor binding sites from DNA sequence using clustered position weight matrices.Nucleic acids research · 2012Article
- Pioneer transcription factors: establishing competence for gene expression.Genes & development · 2011Review
- Conservation of transcription factor binding events predicts gene expression across species.Nucleic acids research · 2011Article
- Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.Cell metabolism · 2011Article
- Finding subtypes of transcription factor motif pairs with distinct regulatory roles.Nucleic acids research · 2011Article
- The nucleosome map of the mammalian liver.Nature structural & molecular biology · 2011Article
- Species-specific strategies underlying conserved functions of metabolic transcription factors.Molecular endocrinology (Baltimore, Md.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Foxa2 is a critical transcription factor that controls liver development and plays an important role in hepatic gluconeogensis in adult mice. Here, we use genome-wide location analysis for Foxa2 to identify its targets in the adult liver. We then show by computational analyses that Foxa2 containing cis-regulatory modules are not constructed from a random assortment of binding sites for other transcription factors expressed in the liver, but rather that their composition depends on the strength of the Foxa2 consensus site present. Genes containing a cis-regulatory module with a medium or weak Foxa2 consensus site are much more liver-specific than the genes with a strong consensus site. We not only provide a better understanding of the mechanisms of Foxa2 regulation but also introduce a novel method for identification of different cis-regulatory modules involving a single factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.