ReviewCurrent opinion in microbiology2008
Natural selection on the Drosophila antimicrobial immune system.
Review in Current opinion in microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 128 citations in OpenAlex.
- Article
- Increased heterozygosity and balancing selection in isofemale generations of Anopheles stephensi under laboratory conditions.BMC genomics · 2025Article
- Investigating the immunomodulatory effects of honeybee venom peptide apamin inInfection and immunity · 2025Article
- MicroRNA Targets PAP1 to Mediate Melanization inInternational journal of molecular sciences · 2024Article
- Article
- Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster.Nature ecology & evolution · 2022Article
- Evolving and assembling to pierce through: Evolutionary and structural aspects of antimicrobial peptides.Computational and structural biotechnology journal · 2022Review
- Macrophages and Their Organ Locations Shape Each Other in Development and Homeostasis - AFrontiers in cell and developmental biology · 2021Review
- Article
- Antimicrobial peptides: Application informed by evolution.Science (New York, N.Y.) · 2020Review
- Antimicrobial peptide and sequence variation along a latitudinal gradient in two anurans.BMC genetics · 2020Article
- Unusual interplay of contrasting selective pressures on β-defensin genes implicated in male fertility of the Buffalo (Bubalus bubalis).BMC evolutionary biology · 2019Article
- Drosophila melanogaster establishes a species-specific mutualistic interaction with stable gut-colonizing bacteria.PLoS biology · 2018Article
- Article
- Antagonistic evolution of an antibiotic and its molecular chaperone: how to maintain a vital ectosymbiosis in a highly fluctuating habitat.Scientific reports · 2017Article
- Rapid Expansion of Immune-Related Gene Families in the House Fly, Musca domestica.Molecular biology and evolution · 2017Article
- A genome-wide scan for genes under balancing selection in Drosophila melanogaster.BMC evolutionary biology · 2017Article
- Isolation and Purification of an Antibacterial Protein from Immune Induced Haemolymph of American Cockroach,Journal of arthropod-borne diseases · 2016Article
- Immune genes and divergent antimicrobial peptides in flies of the subgenus Drosophila.BMC evolutionary biology · 2016Article
- The drosomycin multigene family: three-disulfide variants from Drosophila takahashii possess antibacterial activity.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The evolutionary dynamics of immune defenses have long attracted interest because of the special role the immune system plays in mediating the antagonistic interaction between hosts and pathogens. The antimicrobial immune system of the fruit fly Drosophila melanogaster is genetically well characterized and serves as a valuable model for studying insect and human innate immune defenses. I review here evolutionary and comparative genomic analyses of insect antimicrobial immune genes, with an emphasis on Drosophila. Core signal transduction pathways in the immune system are orthologously conserved across long evolutionary distances, but genes in these pathways evolve rapidly and adaptively at the amino acid sequence level. By contrast, families of genes encoding antimicrobial peptides are remarkably dynamic in genomic duplication and deletion, yet individual genes show little indication of adaptive sequence evolution. Pattern recognition receptors that trigger humoral immunity are evolutionarily rather static, but receptors required for phagocytosis show considerable genomic rearrangement and adaptive sequence divergence. The distinct evolutionary patterns exhibited by these various classes of immune system genes can be logically connected to the functions of the proteins they encode.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.