ReviewCurrent opinion in structural biology2008
Unwinding RNA's secrets: advances in the biology, physics, and modeling of complex RNAs.
Review in Current opinion in structural biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Advances and Mechanisms of RNA-Ligand Interaction Predictions.Life (Basel, Switzerland) · 2025Review
- Base-pair ambiguity and the kinetics of RNA folding.BMC bioinformatics · 2019Article
- Predicting Ion Effects in an RNA Conformational Equilibrium.The journal of physical chemistry. B · 2017Article
- Monte Carlo Tightly Bound Ion Model: Predicting Ion-Binding Properties of RNA with Ion Correlations and Fluctuations.Journal of chemical theory and computation · 2016Article
- A DEAD-box RNA helicase promotes thermodynamic equilibration of kinetically trapped RNA structures in vivo.RNA (New York, N.Y.) · 2016Article
- Dynamic motions of the HIV-1 frameshift site RNA.Biophysical journal · 2015Article
- Double-stranded RNA under force and torque: similarities to and striking differences from double-stranded DNA.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- DEAD-box helicases as integrators of RNA, nucleotide and protein binding.Biochimica et biophysica acta · 2013Review
- Understanding the role of three-dimensional topology in determining the folding intermediates of group I introns.Biophysical journal · 2013Article
- Ion-mediated RNA structural collapse: effect of spatial confinement.Biophysical journal · 2012Article
- Evaluating our ability to predict the structural disruption of RNA by SNPs.BMC genomics · 2012Article
- Predicting ion-nucleic acid interactions by energy landscape-guided sampling.Journal of chemical theory and computation · 2012Article
- Characterization of the kinetic and thermodynamic landscape of RNA folding using a novel application of isothermal titration calorimetry.Nucleic acids research · 2012Article
- Structural effects of linkage disequilibrium on the transcriptome.RNA (New York, N.Y.) · 2012Article
- New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation.Nucleic acids research · 2012Article
- Clustering to identify RNA conformations constrained by secondary structure.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Importance of diffuse metal ion binding to RNA.Metal ions in life sciences · 2011Review
- Predicting ion binding properties for RNA tertiary structures.Biophysical journal · 2010Article
- Network models for molecular kinetics and their initial applications to human health.Cell research · 2010Review
- mRNA secondary structures fold sequentially but exchange rapidly in vivo.PLoS biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The rapid development of our understanding of the diverse biological roles fulfilled by non-coding RNA has motivated interest in the basic macromolecular behavior, structure, and function of RNA. We focus on two areas in the behavior of complex RNAs. First, we present advances in the understanding of how RNA folding is accomplished in vivo by presenting a mechanism for the action of DEAD-box proteins. Members of this family are intimately associated with almost all cellular processes involving RNA, mediating RNA structural rearrangements and chaperoning their folding. Next, we focus on advances in understanding, and characterizing the basic biophysical forces that govern the folding of complex RNAs. Ultimately we expect that a confluence and synergy between these approaches will lead to profound understanding of RNA and its biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.