ArticleJournal of molecular biology2008
Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
Article in Journal of molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling.Cells · 2023Review
- Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenicProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nck adaptors at a glance.Journal of cell science · 2021Article
- Article
- Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology.Frontiers in cell and developmental biology · 2021Review
- Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.The Journal of biological chemistry · 2020Article
- Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.Molecular cell · 2018Article
- Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor.Cell research · 2017Article
- Article
- Nck recruitment to the TCR required for ZAP70 activation during thymic development.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Phosphotyrosine recognition domains: the typical, the atypical and the versatile.Cell communication and signaling : CCS · 2012Article
- Non-catalytic functions of Pyk2 and Fyn regulate late stage adhesion in human T cells.PloS one · 2012Article
- Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function.Clinical and experimental immunology · 2012Article
- Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations.Aging cell · 2011Article
- Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Autoinhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity.Biochemistry · 2010Article
- Organization of proximal signal initiation at the TCR:CD3 complex.Immunological reviews · 2009Review
- Nck adapter proteins: functional versatility in T cells.Cell communication and signaling : CCS · 2009Article
- T cell activation.Annual review of immunology · 2009Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Recruitment of signaling molecules to the cytoplasmic domains of the CD3 subunits of the T-cell receptor (TCR) is crucial for early T-cell activation. These transient associations either do or do not require tyrosine phosphorylation of CD3 immune tyrosine activation motifs (ITAMs). Here we show that the non-ITAM-requiring adaptor protein Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the ITAM and a TCR endocytosis signal. As suggested by the structure of the complex, we find that Nck binding inhibits phosphorylation of the CD3epsilon ITAM by Fyn and Lck kinases in vitro. Moreover, the CD3epsilon-Nck interaction downregulates TCR surface expression upon physiological stimulation in mouse primary lymph node cells. This indicates that Nck performs an important regulatory function in T lymphocytes by inhibiting ITAM phosphorylation and/or removing cell surface TCR via CD3epsilon interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.