ArticleGenome biology2008
Neo-sex chromosomes in the black muntjac recapitulate incipient evolution of mammalian sex chromosomes.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Unique sex chromosome translocations and evolutionary strata in two Sylvioidea songbird families.BMC genomics · 2026Article
- Representing sex chromosomes in genome assemblies.Cell genomics · 2022Article
- Recurrent chromosome reshuffling and the evolution of neo-sex chromosomes in parrots.Nature communications · 2022Article
- Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer.Nature communications · 2021Article
- Meiosis reveals the early steps in the evolution of a neo-XY sex chromosome pair in the African pygmy mouse Mus minutoides.PLoS genetics · 2020Article
- Establishment and evolution of heterochromatin.Annals of the New York Academy of Sciences · 2020Review
- Evolutionary rearrangements of X chromosomes in voles (Arvicolinae, Rodentia).Scientific reports · 2020Article
- Article
- Neo-sex Chromosomes in the Monarch Butterfly,G3 (Bethesda, Md.) · 2017Article
- Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome - Sex Chromosome Translocations.PloS one · 2016Article
- Initiation of recombination suppression and PAR formation during the early stages of neo-sex chromosome differentiation in the Okinawa spiny rat, Tokudaia muenninki.BMC evolutionary biology · 2015Article
- Positive and purifying selection on the Drosophila Y chromosome.Molecular biology and evolution · 2014Article
- Should Y stay or should Y go: the evolution of non-recombining sex chromosomes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Review
- Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.BMC genomics · 2012Article
- Evidence of a neo-sex chromosome in birds.Heredity · 2012Article
- Is there any reproductive future left for men?Facts, views & vision in ObGyn · 2012Article
- Small but mighty: the evolutionary dynamics of W and Y sex chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- The Y chromosome of the Okinawa spiny rat, Tokudaia muenninki, was rescued through fusion with an autosome.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Rapid de novo evolution of X chromosome dosage compensation in Silene latifolia, a plant with young sex chromosomes.PLoS biology · 2012Article
- Is the Y chromosome disappearing?--both sides of the argument.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe regular mammalian X and Y chromosomes diverged from each other at least 166 to 148 million years ago, leaving few traces of their early evolution, including degeneration of the Y chromosome and evolution of dosage compensation.
resultsWe studied the intriguing case of black muntjac, in which a recent X-autosome fusion and a subsequent large autosomal inversion within just the past 0.5 million years have led to inheritance patterns identical to the traditional X-Y (neo-sex chromosomes). We compared patterns of genome evolution in 35-kilobase noncoding regions and 23 gene pairs on the homologous neo-sex chromosomes. We found that neo-Y alleles have accumulated more mutations, comprising a wide variety of mutation types, which indicates cessation of recombination and is consistent with an ongoing neo-Y degeneration process. Putative deleterious mutations were observed in coding regions of eight investigated genes as well as cis-regulatory regions of two housekeeping genes. In vivo assays characterized a neo-Y insertion in the promoter of the CLTC gene that causes a significant reduction in allelic expression. A neo-Y-linked deletion in the 3'-untranslated region of gene SNX22 abolished a microRNA target site. Finally, expression analyses revealed complex patterns of expression divergence between neo-Y and neo-X alleles.
conclusionThe nascent neo-sex chromosome system of black muntjacs is a valuable model in which to study the evolution of sex chromosomes in mammals. Our results illustrate the degeneration scenarios in various genomic regions. Of particular importance, we report--for the first time--that regulatory mutations were probably able to accelerate the degeneration process of Y and contribute to further evolution of dosage compensation.
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