ArticleBMC microbiology2008
Sequencing and expression of two arsenic resistance operons with different functions in the highly arsenic-resistant strain Ochrobactrum tritici SCII24T.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- The key to arsenic pollution remediation: engineering and functional effects of arsenic-resistant microorganisms.World journal of microbiology & biotechnology · 2026Review
- Bacterial Heavy Metal Resistance in Contaminated Soil.Journal of microbiology and biotechnology · 2025Review
- Antimony efflux underpins phosphorus cycling and resistance of phosphate-solubilizing bacteria in mining soils.The ISME journal · 2023Article
- Genome mining to unravel potential metabolic pathways linked to gallium bioleaching ability of bacterial mine isolates.Frontiers in microbiology · 2022Article
- Biochemical, molecular and in silico characterization of arsenate reductase from Bacillus thuringiensis KPWP1 tolerant to salt, arsenic and a wide range of pH.Archives of microbiology · 2021Article
- Diversity and arsenic-metabolizing gene clusters of indigenous arsenate-reducing bacteria in high arsenic groundwater of the Hetao Plain, Inner Mongolia.Ecotoxicology (London, England) · 2021Article
- Isolation and characterization of a halophilic Modicisalibacter sp. strain Wilcox from produced water.Scientific reports · 2021Article
- Introducing the ArsR-Regulated Arsenic Stimulon.Frontiers in microbiology · 2021Article
- Microbes involved in arsenic mobilization and respiration: a review on isolation, identification, isolates and implications.Environmental geochemistry and health · 2020Review
- Arsenic accumulation by a rhizosphere bacterial strain Ochrobactrum tritici reduces rice plant arsenic levels.World journal of microbiology & biotechnology · 2020Article
- Article
- Tailings microbial community profile and prediction of its functionality in basins of tungsten mine.Scientific reports · 2019Article
- Identification of A Novel Arsenic Resistance Transposon Nested in A Mercury Resistance Transposon ofMicroorganisms · 2019Article
- Resistance Gene Carriage Predicts Growth of Natural and ClinicalApplied and environmental microbiology · 2019Article
- Analysis of the ars gene cluster from highly arsenic-resistant Burkholderia xenovorans LB400.World journal of microbiology & biotechnology · 2018Article
- Distribution of Arsenic Resistance Genes in Prokaryotes.Frontiers in microbiology · 2018Review
- Arsenic Detoxification by Geobacter Species.Applied and environmental microbiology · 2017Article
- Comprehensive genomic and phenotypic metal resistance profile of Pseudomonas putida strain S13.1.2 isolated from a vineyard soil.AMB Express · 2016Article
- Paralogous Regulators ArsR1 and ArsR2 of Pseudomonas putida KT2440 as a Basis for Arsenic Biosensor Development.Applied and environmental microbiology · 2016Article
- Regulatory Activities of Four ArsR Proteins in Agrobacterium tumefaciens 5A.Applied and environmental microbiology · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArsenic (As) is a natural metalloid, widely used in anthropogenic activities, that can exist in different oxidation states. Throughout the world, there are several environments contaminated with high amounts of arsenic where many organisms can survive. The most stable arsenical species are arsenate and arsenite that can be subject to chemically and microbiologically oxidation, reduction and methylation reactions. Organisms surviving in arsenic contaminated environments can have a diversity of mechanisms to resist to the harmful effects of arsenical compounds.
resultsThe highly metal resistant Ochrobactrum tritici SCII24 was able to grow in media with arsenite (50 mM), arsenate (up to 200 mM) and antimonite (10 mM). This strain contains two arsenic and antimony resistance operons (ars1 and ars2), which were cloned and sequenced. Sequence analysis indicated that ars1 operon contains five genes encoding the following proteins: ArsR, ArsD, ArsA, CBS-domain-containing protein and ArsB. The ars2 operon is composed of six genes that encode two other ArsR, two ArsC (belonging to different families of arsenate reductases), one ACR3 and one ArsH-like protein. The involvement of ars operons in arsenic resistance was confirmed by cloning both of them in an Escherichia coli ars-mutant. The ars1 operon conferred resistance to arsenite and antimonite on E. coli cells, whereas the ars2 operon was also responsible for resistance to arsenite and arsenate. Although arsH was not required for arsenate resistance, this gene seems to be important to confer high levels of arsenite resistance. None of ars1 genes were detected in the other type strains of genus Ochrobactrum, but sequences homologous with ars2 operon were identified in some strains.
conclusionA new strategy for bacterial arsenic resistance is described in this work. Two operons involved in arsenic resistance, one giving resistance to arsenite and antimonite and the other giving resistance to arsenate were found in the same bacterial strain.
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