ArticleMolecular microbiology2008
Differential expression of Bordetella pertussis iron transport system genes during infection.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Geographic diversity of theFrontiers in veterinary science · 2025Article
- Avirulent phenotype promotesEmerging microbes & infections · 2023Article
- Pathogenicity and virulence ofVirulence · 2021Review
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- Analysis of themSphere · 2019Article
- Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.Medical microbiology and immunology · 2018Review
- Nonredundant Roles of Iron Acquisition Systems in Vibrio cholerae.Infection and immunity · 2016Article
- Interspecies variations in Bordetella catecholamine receptor gene regulation and function.Infection and immunity · 2015Article
- Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin.Accounts of chemical research · 2014Article
- The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague.Infection and immunity · 2012Article
- Iron and pH-responsive FtrABCD ferrous iron utilization system of Bordetella species.Molecular microbiology · 2012Article
- Involvement of multiple distinct Bordetella receptor proteins in the utilization of iron liberated from transferrin by host catecholamine stress hormones.Molecular microbiology · 2012Article
- Hunger for iron: the alternative siderophore iron scavenging systems in highly virulent Yersinia.Frontiers in cellular and infection microbiology · 2012Review
- Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression.Journal of bacteriology · 2011Article
- The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin.Molecular microbiology · 2010Article
- Resemblance and divergence: the "new" members of the genus Bordetella.Medical microbiology and immunology · 2010Review
- The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague.Infection and immunity · 2010Article
- Cross-species protection mediated by a Bordetella bronchiseptica strain lacking antigenic homologs present in acellular pertussis vaccines.Infection and immunity · 2010Article
- Expression of BfrH, a putative siderophore receptor of Bordetella bronchiseptica, is regulated by iron, Fur1, and the extracellular function sigma factor EcfI.Infection and immunity · 2010Article
- Microbial telesensing: probing the environment for friends, foes, and food.Cell host & microbe · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Temporal expression patterns of the Bordetella pertussis alcaligin, enterobactin and haem iron acquisition systems were examined using alcA-, bfeA- and bhuR-tnpR recombinase fusion strains in a mouse respiratory infection model. The iron systems were differentially expressed in vivo, showing early induction of the alcaligin and enterobactin siderophore systems, and delayed induction of the haem system in a manner consistent with predicted changes in host iron source availability during infection. Previous mixed infection competition studies established the importance of alcaligin and haem utilization for B. pertussis in vivo growth and survival. In this study, the contribution of the enterobactin system to the fitness of B. pertussis was confirmed using wild-type and enterobactin receptor mutant strains in similar competition infection experiments. As a correlate to the in vivo expression studies of B. pertussis iron systems in mice, sera from uninfected and B. pertussis-infected human donors were screened for antibody reactivity with Bordetella iron-repressible cell envelope proteins. Pertussis patient sera recognized multiple iron-repressible proteins including the known outer membrane receptors for alcaligin, enterobactin and haem, supporting the hypothesis that B. pertussis is iron-starved and responds to the presence of diverse iron sources during natural infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.