ArticleMolecular microbiology2008
Independence and interdependence of Dif and Frz chemosensory pathways in Myxococcus xanthus chemotaxis.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Milestones in the development ofJournal of bacteriology · 2025Review
- Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1'-Desaturase PEDS1 for Human Plasmalogen Biosynthesis.Frontiers in cell and developmental biology · 2022Review
- Linking single-cell decisions to collective behaviours in social bacteria.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Article
- Agent-Based Modeling Reveals Possible Mechanisms for Observed Aggregation Cell Behaviors.Biophysical journal · 2018Article
- Comparative Genomics of Myxobacterial Chemosensory Systems.Journal of bacteriology · 2018Article
- Data-driven modeling reveals cell behaviors controlling self-organization duringProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Chemosensory signaling systems that control bacterial survival.Trends in microbiology · 2014Review
- Functional organization of a multimodular bacterial chemosensory apparatus.PLoS genetics · 2014Article
- The Azospirillum brasilense Che1 chemotaxis pathway controls swimming velocity, which affects transient cell-to-cell clumping.Journal of bacteriology · 2012Article
- DifA, a methyl-accepting chemoreceptor protein-like sensory protein, uses a novel signaling mechanism to regulate exopolysaccharide production in Myxococcus xanthus.Journal of bacteriology · 2011Article
- Phosphorylation and dephosphorylation among Dif chemosensory proteins essential for exopolysaccharide regulation in Myxococcus xanthus.Journal of bacteriology · 2010Article
- Developments in Defining dif.Journal of bacteriology · 2010Article
- Gliding motility revisited: how do the myxobacteria move without flagella?Microbiology and molecular biology reviews : MMBR · 2010Review
- Isolation and characterization of a suppressor mutation that restores Myxococcus xanthus exopolysaccharide production.Microbiology (Reading, England) · 2009Article
- Upward mobility and alternative lifestyles: a report from the 10th biennial meeting on Bacterial Locomotion and Signal Transduction.Molecular microbiology · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dif and Frz, two Myxococcus xanthus chemosensory pathways, are required in phosphatidylethanolamine (PE) chemotaxis for excitation and adaptation respectively. DifA and FrzCD, the homologues of methyl-accepting chemoreceptors in the two pathways, were examined for methylation in the context of chemotaxis and inter-pathway interactions. Evidence indicates that DifA may not undergo methylation, but signals transmitting through DifA do modulate FrzCD methylation. Results also revealed that M. xanthus possesses Dif-dependent and Dif-independent PE-sensing mechanisms. Previous studies showed that FrzCD methylation is decreased by negative chemostimuli but increased by attractants such as PE. Results here demonstrate that the Dif-dependent sensory mechanism suppresses the increase in FrzCD methylation in attractant response and elevates FrzCD methylation upon negative stimulation. In other words, FrzCD methylation is governed by opposing forces from Dif-dependent and Dif-independent sensing mechanisms. We propose that the Dif-independent but Frz-dependent PE sensing leads to increases in FrzCD methylation and subsequent adaptation, while the Dif-dependent PE signalling suppresses or diminishes the increase in FrzCD methylation to decelerate or delay adaptation. We contend that these antagonistic interactions are crucial for effective chemotaxis in this gliding bacterium to ensure that adaptation does not occur too quickly relative to the slow speed of M. xanthus movement.
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