ArticleMolecular and cellular biochemistry2008
Energetic metabolism during acute stretch-related atrial fibrillation.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Characterisation of Ventricular Nucleotide Metabolism and Clinical Predictors Associated with the Onset of Atrial Fibrillation Following Cardiac Surgery.Journal of clinical medicine · 2025Article
- Relaxin-2 Exhibits a Beneficial Role in Energy Metabolism to Alleviate Atrial Fibrillation Susceptibility.ACS pharmacology & translational science · 2025Article
- The ratio of cytochrome c oxidase subunit 4 isoform 4I1 and 4I2 mRNA is changed in permanent atrial fibrillation.ESC heart failure · 2024Article
- Long non-coding RNA and circular RNA: new perspectives for molecular pathophysiology of atrial fibrillation.Molecular biology reports · 2023Review
- Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices.GeroScience · 2023Article
- New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report.The Journal of international medical research · 2022Article
- Review
- Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model.JCI insight · 2022Article
- Left atrial posterior wall isolation in conjunction with pulmonary vein isolation using cryoballoon for treatment of persistent atrial fibrillation (PIVoTAL): study rationale and design.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- Rationale and Outcomes of Cryoballoon Ablation of the Left Atrial Posterior Wall in Conjunction with Pulmonary Vein Isolation.The Journal of innovations in cardiac rhythm management · 2021Article
- Fetal cardiomyocyte phenotype, ketone body metabolism, and mitochondrial dysfunction in the pathology of atrial fibrillation.Molecular and cellular biochemistry · 2021Review
- Posterior Wall Isolation in Atrial Fibrillation Ablation.The Journal of innovations in cardiac rhythm management · 2018Review
- Metoprolol prevents chronic obstructive sleep apnea-induced atrial fibrillation by inhibiting structural, sympathetic nervous and metabolic remodeling of the atria.Scientific reports · 2017Article
- A Method Sustaining the Bioelectric, Biophysical, and Bioenergetic Function of Cultured Rabbit Atrial Cells.Frontiers in physiology · 2017Article
- Selective downregulation of mitochondrial electron transport chain activity and increased oxidative stress in human atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2016Article
- β3-Adrenoceptor Impairs Mitochondrial Biogenesis and Energy Metabolism During Rapid Atrial Pacing-Induced Atrial Fibrillation.Journal of cardiovascular pharmacology and therapeutics · 2016Article
- Patient-specific flexible and stretchable devices for cardiac diagnostics and therapy.Progress in biophysics and molecular biology · 2014Review
- Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
methodsPerturbations in energetic metabolism and impaired atrial contractility may play an important role in the pathogenesis of atrial fibrillation (AF). Besides, atrial stretch is commonly associated with AF. However, the atrial energetics of stretch-related AF are poorly understood. Here, we measured indicators of energy metabolism during acute stretch-related AF. PCr, adenine nucleotides, and derivatives concentrations as well as the activity of the F(0)F(1)-ATPase and Na,K-ATPase were obtained after 1 h of stretch and/or AF in isolated rabbit hearts and compared to control hearts without stretch and AF.
resultsAfter 1 h of stretch-related AF, the total adenine nucleotides' pool was significantly lower (42.2 +/- 2.6 vs. 63.7 +/- 8.3 micromol/g protein in control group, P < 0.05) and the PCr/ATP ratio significantly higher (2.3 +/- 0.3 vs. 1.1 +/- 0.1 in control group P < 0.05), because of ATP, ADP, and AMP decrease and PCr increase. The sum of high-energy phosphate compounds did not change. There were no significant differences in F(0)F(1)-ATPase nor Na,K-ATPase activity between the groups.
conclusionsResults show that in this experimental model, acute stretch-related AF induces specific modifications of atrial myocytes energetics that may play a pivotal role in the perpetuation of the arrhythmia.
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