ArticleInternational journal of legal medicine2009
Genomic complexity of the Y-STR DYS19: inversions, deletions and founder lineages carrying duplications.
Article in International journal of legal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Molecular characterization of the Yp11.2 region deletion in the Chinese Han population.International journal of legal medicine · 2021Article
- Deletions and duplications of 42 Y chromosomal short tandem repeats in Chinese Han population.International journal of legal medicine · 2021Article
- Development of the Kazakhstan Y-chromosome haplotype reference database: analysis of 27 Y-STR in Kazakh population.International journal of legal medicine · 2019Article
- The Y chromosome as the most popular marker in genetic genealogy benefits interdisciplinary research.Human genetics · 2017Review
- Copy number variation in the human Y chromosome in the UK population.Human genetics · 2015Article
- The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades.Molecular biology and evolution · 2015Article
- Y chromosome interstitial deletion induced Y-STR allele dropout in AMELY-negative individuals.International journal of legal medicine · 2012Article
- Mitochondrial DNA and Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians.American journal of human genetics · 2012Article
- Comprehensive mutation analysis of 17 Y-chromosomal short tandem repeat polymorphisms included in the AmpFlSTR Yfiler PCR amplification kit.International journal of legal medicine · 2009Article
- Kinship and Y-chromosome analysis of 7th century human remains: novel DNA extraction and typing procedure for ancient material.Croatian medical journal · 2009Article
- Genetic sub-structure in western Mediterranean populations revealed by 12 Y-chromosome STR loci.International journal of legal medicine · 2009Article
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Authors and funding
13 authors at 10 institutions in 4 countries.
Funding
Abstract
The Y-STR DYS19 is firmly established in the repertoire of Y-chromosomal markers used in forensic analysis yet is poorly understood at the molecular level, lying in a complex genomic environment and exhibiting null alleles, as well as duplications and occasional triplications in population samples. Here, we analyse three null alleles and 51 duplications and show that DYS19 can also be involved in inversion events, so that even its location within the short arm of the Y chromosome is uncertain. Deletion mapping in the three chromosomes carrying null alleles shows that their deletions are less than approximately 300 kb in size. Haplotypic analysis with binary markers shows that they belong to three different haplogroups and so represent independent events. In contrast, a collection of 51 DYS19 duplication chromosomes belong to only four haplogroups: two are singletons and may represent somatic mutation in lymphoblastoid cell lines, but two, in haplogroups G and C3c, represent founder lineages that have spread widely in Central Europe/West Asia and East Asia, respectively. Consideration of candidate mechanisms underlying both deletions and duplications provides no evidence for the involvement of non-allelic homologous recombination, and they are likely to represent sporadic events with low mutation rates. Understanding the basis and population distribution of these DYS19 alleles will aid in the utilisation and interpretation of profiles that contain them.
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