Evidence map›Paper›PMID 18552864›Full record

ReviewNature reviews. Microbiology2008

Viral infection and iron metabolism.

Hal Drakesmith, Andrew Prentice

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04333550 (Application of Iron Chelator), which is not on this map. Cited by 230 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 7 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04333550 phase1 / phase2unknown statusnot on this mapstarted 2020, after this paper: background citation

Application of Iron Chelator (Desferal) to Reduce the Severity of COVID-19 Manifestations

TypeinterventionalSponsorKermanshah University of Medical SciencesRan2020 to 2021Enrolled50ConditionsCOVID-19ArmsDeferoxamine
3 · Its place in the literature

Who cites it

230 citing papers in PubMed, 7 syntheses or guidelines pooled it, 474 citations in OpenAlex.

  1. Pooled it
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  12. Review
  13. Ferroptosis in liver biology and diseases.Hepatology communications · 2026
    Review
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170 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hal DrakesmithMolecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital and Oxford University, Oxford OX3 9DS, UK. hdrakes@hammer.imm.ox.ac.uk
Andrew Prentice
John Radcliffe Hospital · GBMRC Human Immunology Unit · GB

Funding

Medical Research Council G0700844Wellcome Trust
6 · The paper itself

Abstract

Fundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron-replete host. Some viruses selectively infect iron-acquiring cells by binding to transferrin receptor 1 during cell entry. Other viruses alter the expression of proteins involved in iron homeostasis, such as HFE and hepcidin. In HIV-1 and hepatitis C virus infections, iron overload is associated with poor prognosis and could be partly caused by the viruses themselves. Understanding how iron metabolism and viral infection interact might suggest new methods to control disease.

Indexed as

AnimalsAntimicrobial Cationic PeptidesHepcidinsHomeostasisHumansIronIron OverloadVirus DiseasesVirus ReplicationAntimicrobial Cationic PeptidesHAMP protein, humanHepcidinsIron

Identifiers

PMID18552864
OpenAlexW1989978580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.