ArticleNature structural & molecular biology2008
Supramolecular SNARE assembly precedes hemifusion in SNARE-mediated membrane fusion.
Article in Nature structural & molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Full-length SARS-CoV-2 envelope protein adopts an interfacial topology in lipid bilayers.Biochimica et biophysica acta. Biomembranes · 2026Article
- VAMP8 Is an Endosomal v-SNARE That Supports GLP-1 Receptor Recycling in Pancreatic β-Cells.Diabetes · 2025Article
- Membrane fusion byMolecular biology of the cell · 2022Article
- The Magnetosome Protein, Mms6 fromInternational journal of molecular sciences · 2022Article
- SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- t-SNARE Transmembrane Domain Clustering Modulates Lipid Organization and Membrane Curvature.Journal of the American Chemical Society · 2017Article
- Metal-dependent SpoIIE oligomerization stabilizes FtsZ during asymmetric division in Bacillus subtilis.PloS one · 2017Article
- The Multifaceted Role of SNARE Proteins in Membrane Fusion.Frontiers in physiology · 2017Review
- Article
- Exploring the Formation and the Structure of Synaptobrevin Oligomers in a Model Membrane.Biophysical journal · 2016Article
- Article
- Synaptobrevin Transmembrane Domain Dimerization Studied by Multiscale Molecular Dynamics Simulations.Biophysical journal · 2015Article
- Examination of Sec22 Homodimer Formation and Role in SNARE-dependent Membrane Fusion.The Journal of biological chemistry · 2015Article
- The synaptotagmin juxtamembrane domain is involved in neuroexocytosis.FEBS open bio · 2015Article
- The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.Cellular and molecular life sciences : CMLS · 2014Review
- Lipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter release.Neuron · 2013Article
- Adhesion energy can regulate vesicle fusion and stabilize partially fused states.Journal of the Royal Society, Interface · 2012Article
- Syntaxin1A lateral diffusion reveals transient and local SNARE interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The SM protein Vps33 and the t-SNARE H(abc) domain promote fusion pore opening.Nature structural & molecular biology · 2010Article
- Fluorescence applications in molecular neurobiology.Neuron · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Formation of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex facilitates intracellular membrane fusion. A single SNARE complex is thought to be insufficient; multiple copies of SNARE complexes must work cooperatively. However, the mechanism by which such a higher-order SNARE protein structure is assembled is unknown. EPR and fluorescence analyses show that at least three copies of target-membrane SNARE proteins self-assemble through the interaction between the transmembrane domains (TMDs), and this multimeric structure serves as scaffolding for trans-SNARE assembly. SNARE core formation in solution induces oligomerization of the TMDs of vesicle-associated SNAREs in the apposing membrane, transiently forming a supramolecular protein structure spanning two membranes. This higher-order protein intermediate evolves, by involving lipid molecules, to the hemifusion state. Hemifusion is subsequently followed by distal leaflet mixing and formation of the cis-SNARE complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.