Evidence map›Paper›PMID 18552463›Full record

ReviewInternal medicine (Tokyo, Japan)2008

Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains.

Yoshio Yamaoka, Mototsugu Kato, Masahiro Asaka

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. A Comprehensive Survey of the Relationship betweenArchives of Iranian medicine · 2022
    Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Effect of treatment failure on the CagA EPIYA motif inWorld journal of gastroenterology · 2017
    Trial
  9. Trial
  10. Article
  11. Article
  12. Article
  13. Review
  14. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  15. Journal of medical microbiology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yoshio YamaokaDepartment of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Texas, USA. yyamaoka@bcm.tmc.edu
Mototsugu Kato
Masahiro Asaka

Funding

REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORIR01DK062813 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI YAMAOKA, YOSHIO · 2004 to 2013
$3.0M
NIDDK NIH HHS DK62813NIDDK NIH HHS R01 DK062813
6 · The paper itself

Abstract

Certain populations with high incidences of Helicobacter pylori infection, such as those in East Asian countries, have high incidences of gastric cancer, while other highly infected populations, such as those in Africa and South Asia, do not. The various rates of gastric cancer associated with different geographic areas can be explained, at least in part, by the differences in the genotypes of H. pylori cagA and vacA. Populations expressing a high incidence of gastric cancer are mostly identical with regions where East Asian type CagA is predominant. In contrast, incidence of gastric cancer is low in Africa, South Asia, and Europe, where strains typically possess Western type CagA. Within East Asia, strains from northern parts, where the incidence of gastric cancer is high, predominantly possess the vacA m1 genotype, whereas the m2 genotype is predominant in southern parts where the gastric cancer incidence is low.

Indexed as

Antigens, BacterialBacterial ProteinsGenotypeGlobal HealthHelicobacter InfectionsHelicobacter pyloriHumansIncidenceStomach NeoplasmsVirulenceAntigens, BacterialBacterial ProteinscagA protein, Helicobacter pyloriVacA protein, Helicobacter pylori

Identifiers

PMID18552463
PMCPMC3732488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.