ArticleThe Journal of biological chemistry2008
Biophysical properties of cadherin bonds do not predict cell sorting.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Freezing shortens the lifetime of DNA molecules under tension.Journal of biological physics · 2017Article
- Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells.Cold Spring Harbor perspectives in biology · 2017Review
- Article
- Biophysical Tools to Study Cellular Mechanotransduction.Bioengineering (Basel, Switzerland) · 2017Review
- Cadherins mediate sequential roles through a hierarchy of mechanisms in the developing mammillary body.Frontiers in neuroanatomy · 2015Article
- Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand.Journal of the Royal Society, Interface · 2014Article
- Cell adhesion and sorting in embryoid bodies derived from N- or E-cadherin deficient murine embryonic stem cells.Biology open · 2014Article
- Ephrin-Eph signaling in embryonic tissue separation.Cell adhesion & migration · 2014Review
- Tuning the kinetics of cadherin adhesion.The Journal of investigative dermatology · 2013Review
- Three functions of cadherins in cell adhesion.Current biology : CB · 2013Review
- Fine tuning of tissues' viscosity and surface tension through contractility suggests a new role for α-catenin.PloS one · 2013Article
- Ideal, catch, and slip bonds in cadherin adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Cadherin recognition and adhesion.Current opinion in cell biology · 2012Review
- Cadherin-dependent mechanotransduction depends on ligand identity but not affinity.Journal of cell science · 2012Article
- Cadherin point mutations alter cell sorting and modulate GTPase signaling.Journal of cell science · 2012Article
- Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis.Cold Spring Harbor perspectives in biology · 2012Review
- The role of adhesion energy in controlling cell-cell contacts.Current opinion in cell biology · 2011Review
- Quantification of the forces driving self-assembly of three-dimensional microtissues.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.Physiological reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Differential binding between cadherin subtypes is widely believed to mediate cell sorting during embryogenesis. However, a fundamental unanswered question is whether cell sorting is dictated by the biophysical properties of cadherin bonds, or by broader, cadherin-dependent differences in intercellular adhesion or membrane tension. This report describes atomic force microscope measurements of the strengths and dissociation rates of homophilic and heterophilic cadherin (CAD) bonds. Measurements conducted with chicken N-CAD, canine E-CAD, and Xenopus C-CAD demonstrated that all three cadherins cross-react and form multiple, intermolecular bonds. The mechanical and kinetic properties of the heterophilic bonds are similar to the homophilic interactions. The thus quantified bond parameters, together with previously reported adhesion energies were further compared with in vitro cell aggregation and sorting assays, which are thought to mimic in vivo cell sorting. Trends in quantified biophysical properties of the different cadherin bonds do not correlate with sorting outcomes. These results suggest that cell sorting in vivo and in vitro is not governed solely by biophysical differences between cadherin subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.