Evidence map›Paper›PMID 18552381›Full record

ArticleInvestigative ophthalmology & visual science2008

Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma.

David J Calkins, Philip J Horner, Robin Roberts, Marius Gradianu, Bruce A Berkowitz

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 52 citations in OpenAlex.

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  11. Glaucoma: the retina and beyond.Acta neuropathologica · 2016
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  13. Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels.Proceedings of the National Academy of Sciences of the United States of America · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David J CalkinsDepartment of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Philip J Horner
Robin Roberts
Marius Gradianu
Bruce A Berkowitz
University of Washington · USVanderbilt University Medical Center · US

Funding

NMR STUDIES OF PRERETINAL NEOVASCULARIZATIONR01EY010221 · NEI · WAYNE STATE UNIVERSITY · PI BERKOWITZ, BRUCE A. · 1995 to 2001
$421k
NEI NIH HHS EY010221NEI NIH HHS R01 EY010221
6 · The paper itself

Abstract

purposeTo test the hypothesis that manganese-enhanced magnetic resonance imaging (MEMRI) is a sensitive approach for measuring of age-related ocular changes in experimental pigmentary glaucoma.

methodsFour groups of light-adapted mice were studied using MEMRI: young (2-3 months), C57BL/6 (negative controls), and DBA/2J mice and aged (10-11 months) C57BL/6 and DBA/2J mice. In all mice, eye perimeter, optic nerve head width, iridocorneal angle, ciliary body area, and total and inner retinal thickness, and a surrogate of retinal ion regulation (intraretinal uptake of manganese) were assessed from MEMRI data and compared. Axon counts were obtained from optic nerves harvested from MEMRI-assessed eyes.

resultsAs the C57BL/6 and DBA/2J mice aged, differential and significant changes in ocular perimeter, retinal thickness, iridocorneal angle, ciliary body area, and optic nerve head width were readily measured from MEMRI data (P < 0.05). In C57BL/6 mice, only inner retinal thickness and perimeter were correlated. In DBA/2J mice, ocular perimeter was correlated with total and inner retinal thickness, ciliary body area, optic nerve head width, and iridocorneal angle. Comparison of young and aged mice revealed a subnormal intraretinal manganese uptake (P < 0.05) in aged DBA/2J mice, but not in aged C57BL/6 mice. Manganese uptake did not correlate with the ocular perimeter. Axon density in the optic nerve correlated with MEMRI-measured optic nerve head width (P < 0.05).

conclusionsThese studies provide a baseline of noninvasive MEMRI-detectable changes associated with age in a common animal model of hereditary glaucoma that may be useful in the longitudinal evaluation of therapeutic success.

Indexed as

ManganeseTrace ElementsAnimalsAxonsCiliary BodyDisease Models, AnimalFollow-Up StudiesGlaucoma, Open-AngleMagnetic Resonance ImagingMiceMice, Inbred C57BLMice, Inbred DBAOptic DiskReproducibility of ResultsRetinaSeverity of Illness IndexManganeseTrace Elements

Identifiers

PMID18552381
PMCPMC2586056
OpenAlexW2002826162

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.