ArticleEukaryotic cell2008
Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Toxoplasma protein export and effector function.Nature microbiology · 2024Review
- Article
- ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons.PLoS pathogens · 2023Article
- Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.International journal for parasitology · 2020Review
- Contribution of introns to the species diversity associated with the apicomplexan parasite, Neospora caninum.Parasitology research · 2020Article
- Generation of Toxoplasma gondii and Hammondia hammondi Oocysts and Purification of Their Sporozoites for Downstream Manipulation.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Dissection of theeLife · 2018Article
- The Expressed MicroRNA-mRNA Interactions ofFrontiers in microbiology · 2017Article
- Host Mitochondrial Association Evolved in the Human Parasite Toxoplasma gondii via Neofunctionalization of a Gene Duplicate.Genetics · 2016Article
- Hammondia hammondi harbors functional orthologs of the host-modulating effectors GRA15 and ROP16 but is distinguished from Toxoplasma gondii by a unique transcriptional profile.Eukaryotic cell · 2014Article
- Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response.PLoS biology · 2014Article
- Toxoplasma transcription factor TgAP2XI-5 regulates the expression of genes involved in parasite virulence and host invasion.The Journal of biological chemistry · 2013Article
- A HT/PEXEL motif in Toxoplasma dense granule proteins is a signal for protein cleavage but not export into the host cell.Traffic (Copenhagen, Denmark) · 2013Article
- Hammondia hammondi, an avirulent relative of Toxoplasma gondii, has functional orthologs of known T. gondii virulence genes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization.Frontiers in microbiology · 2013Article
- Genetic mapping and coccidial parasites: past achievements and future prospects.Journal of biosciences · 2012Review
- Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Article
- Advances in parasite genomics: from sequences to regulatory networks.PLoS pathogens · 2009Article
- Development of forward genetics in Toxoplasma gondii.International journal for parasitology · 2009Review
- Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in mice.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Toxoplasma gondii is an intracellular parasite with a significant impact on human health, especially in cases where individuals are immunocompromised (e.g., due to human immunodeficiency virus/AIDS). In Europe and North America, only a few clonal genotypes appear to be responsible for the vast majority of Toxoplasma infections, and these clonotypes have been intensely studied to identify strain-specific phenotypes that may play a role in the manifestation of more-severe disease. To identify and genetically map strain-specific differences in gene expression, we have carried out expression quantitative trait locus analysis on Toxoplasma gene expression phenotypes by using spotted cDNA microarrays. This led to the identification of 16 Toxoplasma genes that had significant and mappable strain-specific variation in hybridization intensity. While the analysis should identify both cis- and trans-mapping hybridization profiles, we identified only loci with strain-specific hybridization differences that are most likely due to differences in the locus itself (i.e., cis mapping). Interestingly, a larger number of these cis-mapping genes than would be expected by chance encode either confirmed or predicted secreted proteins, many of which are known to localize to the specialized secretory organelles characteristic of members of the phylum Apicomplexa. For six of the cis-mapping loci, we determined if the strain-specific hybridization differences were due to true transcriptional differences or rather to strain-specific differences in hybridization efficiency because of extreme polymorphism and/or deletion, and we found examples of both scenarios.
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