ArticlePlant physiology2008
Metabolome analysis of biosynthetic mutants reveals a diversity of metabolic changes and allows identification of a large number of new compounds in Arabidopsis.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed.
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- The secreted PAMP-induced peptide StPIP1_1 activates immune responses in potato.Scientific reports · 2023Article
- Plant and microbial sciences as key drivers in the development of metabolomics research.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Unravelling the Phytotoxic Effects of Glyphosate on Sensitive and ResistantPlants (Basel, Switzerland) · 2023Article
- Metabolomics as a Potential Chemotaxonomical Tool: Application on the SelectedPlants (Basel, Switzerland) · 2023Article
- A New Strategy Based on LC-Q TRAP-MS for Determining the Distribution of Polyphenols in Different Apple Varieties.Foods (Basel, Switzerland) · 2022Article
- Comparative Metabolomics Reveals Key Determinants in the Flavor and Nutritional Value of Coconut by HS-SPME/GC-MS and UHPLC-MS/MS.Metabolites · 2022Article
- A dirigent family protein confers variation of Casparian strip thickness and salt tolerance in maize.Nature communications · 2022Article
- Mining plant metabolomes: Methods, applications, and perspectives.Plant communications · 2021Review
- Retrograde sulfur flow from glucosinolates to cysteine inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Seed-coat protective neolignans are produced by the dirigent protein AtDP1 and the laccase AtLAC5 in Arabidopsis.The Plant cell · 2021Article
- Article
- Differences in Alternative Splicing between Yellow and Black-Seeded Rapeseed.Plants (Basel, Switzerland) · 2020Article
- Early Pep-13-induced immune responses are SERK3A/B-dependent in potato.Scientific reports · 2019Article
- Emerging strategies for the identification of protein-metabolite interactions.Journal of experimental botany · 2019Article
- Genetic and Phytochemical Characterization of Lettuce Flavonoid Biosynthesis Mutants.Scientific reports · 2019Article
- Insight Into the Prospects for the Improvement of Seed Starch in Legume-A Review.Frontiers in plant science · 2019Review
- Discovery of the Potential Biomarkers for Discrimination betweenMolecules (Basel, Switzerland) · 2018Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Metabolomics is facing a major challenge: the lack of knowledge about metabolites present in a given biological system. Thus, large-scale discovery of metabolites is considered an essential step toward a better understanding of plant metabolism. We show here that the application of a metabolomics approach generating structural information for the analysis of Arabidopsis (Arabidopsis thaliana) mutants allows the efficient cataloging of metabolites. Fifty-six percent of the features that showed significant differences in abundance between seeds of wild-type, transparent testa4, and transparent testa5 plants could be annotated. Seventy-five compounds were structurally characterized, 21 of which could be identified. About 40 compounds had not been known from Arabidopsis before. Also, the high-resolution analysis revealed an unanticipated expansion of metabolic conversions upstream of biosynthetic blocks. Deficiency in chalcone synthase results in the increased seed-specific biosynthesis of a range of phenolic choline esters. Similarly, a lack of chalcone isomerase activity leads to the accumulation of various naringenin chalcone derivatives. Furthermore, our data provide insight into the connection between p-coumaroyl-coenzyme A-dependent pathways. Lack of flavonoid biosynthesis results in elevated synthesis not only of p-coumarate-derived choline esters but also of sinapate-derived metabolites. However, sinapoylcholine is not the only accumulating end product. Instead, we observed specific and sophisticated changes in the complex pattern of sinapate derivatives.
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