ArticleApplied and environmental microbiology2008
Environmental and growth phase regulation of the Streptococcus gordonii arginine deiminase genes.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- The ArgR-Regulated ADI Pathway Facilitates the Survival ofInternational journal of molecular sciences · 2024Article
- Heterogeneous lineage-specific arginine deiminase expression within dental microbiome species.Microbiology spectrum · 2024Article
- Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.Microbiology and molecular biology reviews : MMBR · 2024Review
- Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci.Journal of bacteriology · 2023Article
- The arginine deaminase system plays distinct roles in Borrelia burgdorferi and Borrelia hermsii.PLoS pathogens · 2022Article
- Global transcriptomic analysis of functional oligosaccharide metabolism in Pediococcus pentosaceus.Applied microbiology and biotechnology · 2021Article
- Transcriptomic Analysis ofFrontiers in microbiology · 2021Article
- Murine Salivary Amylase Protects AgainstFrontiers in physiology · 2021Article
- Arginine Metabolism in Supragingival Oral Biofilms as a Potential Predictor of Caries Risk.JDR clinical and translational research · 2019Article
- Metagenome sequencing-based strain-level and functional characterization of supragingival microbiome associated with dental caries in children.Journal of oral microbiology · 2019Article
- MnmE, a Central tRNA-Modifying GTPase, Is Essential for the Growth, Pathogenicity, and Arginine Metabolism ofFrontiers in cellular and infection microbiology · 2019Article
- Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins.Frontiers in microbiology · 2019Article
- Potential Uses of Arginine in Dentistry.Advances in dental research · 2018Review
- Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.Caries research · 2018Article
- A new arginine-based dental adhesive system: formulation, mechanical and anti-caries properties.Journal of dentistry · 2017Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- FlpS, the FNR-Like Protein of Streptococcus suis Is an Essential, Oxygen-Sensing Activator of the Arginine Deiminase System.Pathogens (Basel, Switzerland) · 2016Article
- Amino Sugars Enhance the Competitiveness of Beneficial Commensals with Streptococcus mutans through Multiple Mechanisms.Applied and environmental microbiology · 2016Article
- A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans.Applied and environmental microbiology · 2016Article
- Arginine-Ornithine Antiporter ArcD Controls Arginine Metabolism and Interspecies Biofilm Development of Streptococcus gordonii.The Journal of biological chemistry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A 1,026-bp open reading frame sharing significant similarity with queA, which encodes a predicted S-adenosylmethionine:tRNA ribosyltransferase-isomerase responsible for queosine modification of tRNAs, was found immediately 5' of the gene for the transcriptional activator (ArcR) of the arginine deiminase system (ADS) operon of Streptococcus gordonii. The role of QueA in bacterial physiology is enigmatic, but loss of QueA has been shown to compromise stationary-phase survival or virulence in certain enteric bacteria. Interestingly, S. gordonii appears to be unique among ADS-positive bacteria in the linkage of queA with the ADS genes. A putative sigma(70) promoter (p(queA); TTGCCA-N(21)-TATAAT) was mapped 5' of queA by primer extension, and queA and arcR were shown to be cotranscribed. The expression from p(queA) was found to be constitutive under all conditions tested, but the expression of p(arcA), which drives the expression of the arc structural genes, was enhanced in stationary phase and could be induced by low pH and arginine. QueA and CcpA acted repressively on arc transcription, but neither QueA-deficient strains nor CcpA-deficient strains showed significant differences in arginine deiminase enzyme activities compared with the wild-type strain. The growth rate of a QueA-deficient strain did not differ significantly from that of the parental strain, but the QueA-deficient strain did not compete well with the wild-type during serial passage. In addition to the finding that ADS expression can be regulated separately by growth phase and pH, a significant linkage between the ADS, translational efficiency modulated by QueA, and post-exponential-phase survival of S. gordonii was found.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.