ArticleJournal of clinical immunology2008
IgA anti-b2GPI antibodies in patients with autoimmune liver diseases.
Article in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Diagnostic potential of salivary biomarkers for primary biliary cholangitis: a systematic review.Frontiers in medicine · 2025Pooled it
- From thrombosis to transplantation: The role of anti-phospholipid antibodies in liver disease management.iLIVER · 2025Review
- Anticardiolipin and anti-beta 2-glycoprotein I antibodies in patients with unexplained articular manifestations.Journal of clinical laboratory analysis · 2023Article
- The Weight of IgA Anti-β2glycoprotein I in the Antiphospholipid Syndrome Pathogenesis: Closing the Gap of Seronegative Antiphospholipid Syndrome.International journal of molecular sciences · 2020Review
- Red Blood Cell Distribution Width-to-Platelet Ratio and Other Laboratory Indices Associated with Severity of Histological Hepatic Fibrosis in Patients with Autoimmune Hepatitis: A Retrospective Study at a Single Center.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Antı-β2 Glycoprotein I Antibodies in Children with Rheumatologic Disorders.Indian journal of clinical biochemistry : IJCB · 2019Article
- The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome.Antibodies (Basel, Switzerland) · 2016Review
- Differential assay reactivity of immunglobulin A anti-ßEuropean journal of rheumatology · 2015Article
- Prevalence, significance and predictive value of antiphospholipid antibodies in Crohn's disease.World journal of gastroenterology · 2015Article
- Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics.World journal of gastroenterology · 2015Review
- High frequency of antiphospholipid antibodies in primary biliary cirrhosis.Journal of clinical laboratory analysis · 2015Article
- Serum immunoglobulin A concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease.World journal of gastroenterology · 2014Article
- Autoantibodies in primary biliary cirrhosis: recent progress in research on the pathogenetic and clinical significance.World journal of gastroenterology · 2014Review
- Value of isolated IgA anti-β2 -glycoprotein I positivity in the diagnosis of the antiphospholipid syndrome.Arthritis and rheumatism · 2013Article
- Primary biliary cirrhosis in HBV and HCV patients: Clinical characteristics and outcome.World journal of hepatology · 2013Article
- Clinical significance of IgA anti-cardiolipin and IgA anti-β2glycoprotein I antibodies.Current rheumatology reports · 2013Review
- Tuberculosis is not a risk factor for primary biliary cirrhosis: a review of the literature.Tuberculosis research and treatment · 2012Article
- Rheumatoid arthritis and primary biliary cirrhosis: cause, consequence, or coincidence?Arthritis · 2012Article
- Primary biliary cirrhosis: what do autoantibodies tell us?World journal of gastroenterology · 2010Review
- Early primary biliary cirrhosis: a new association with erythema nodosum of unknown origin.Gastroenterology research and practice · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecently, we reported a high prevalence of immunoglobulin G and/or immunoglobulin M anticardiolipin antibodies (aCL) in patients with autoimmune liver diseases, namely, autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), which were independent of the respective isotypes of antibodies against beta2-glycoprotein I (anti-b2GPI). Immunoglobulin A (IgA) aCL and IgA anti-b2GPI are the least studied of the three specific isotypes either in antiphospholipid syndrome (APS) or in other conditions.
methodsTherefore, we investigated the prevalence and clinical significance of IgA anti-b2GPI and IgA aCL by enzyme-linked immunosorbent assays in another set of Caucasian patients with autoimmune liver diseases (59 AIH, 96 PBC, and 37 PSC). The disease controls group consisted of 50 hepatitis C virus (HCV) patients, 50 hepatitis B virus (HBV), 30 alcoholic liver disease (ALD), 30 non-alcoholic steatohepatitis (NASH), and 110 healthy controls. RESULTS AND DISCUSSION: IgA anti-b2GPI prevalence was higher in AIH (50.8%) compared to PBC (p = 0.005), PSC (p = 0.008), NASH (p = 0.004), ALD (p = 0.01), and HCV (p = 0.002). The titers were also significantly higher in AIH compared to any other group of the study. IgA aCL prevalence was higher in AIH (33.9%) compared to PBC (p = 0.005), PSC (p = 0.014), NASH (p = 0.001), ALD (p = 0.004), and HCV (p < 0.001). IgA anti-b2GPI or IgA aCL were not associated with APS features in patients with liver autoimmunity. Of note, IgA anti-b2GPI and IgA aCL were associated with clinical and biochemical markers of disease severity in AIH and PBC. We demonstrated a high prevalence and high titers of IgA anti-b2GPI in patients with AIH compared to any other liver disease of the study.
conclusionIgA anti-b2GPI and IgA aCL were associated with the severity and biochemical activity of AIH and PBC, but long-term prospective studies are needed to address whether this new finding is of clinical importance in AIH and PBC patients.
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