ReviewJournal of hypertension2008
Development of heart failure in recent hypertension trials.
Review in Journal of hypertension, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 132 citations in OpenAlex.
- Natriuretic peptides and cardiac troponins in hypertension and heart failure: A contemporary review of the evidence.Journal of human hypertension · 2026Review
- Evaluation of Hypertension in Pediatric Hemolytic Uremic Syndrome (A Cross-Sectional Study).Health science reports · 2025Article
- Correlation of systolic and diastolic blood pressure with echocardiographic phenotypes of cardiac structure and function from three German population-based studies.Scientific reports · 2023Article
- Heart Failure Prevalence Rates and Its Association with Other Cardiovascular Diseases and Chronic Kidney Disease: SIMETAP-HF Study.Journal of clinical medicine · 2023Article
- Characterization of Inclination Analysis for Predicting Onset of Heart Failure from Primary Care Electronic Medical Records.Sensors (Basel, Switzerland) · 2023Article
- Blood pressure per the 2017 ACC/AHA and 2018 ESC/ESH guidelines and heart failure risk: the Suita Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Anti-apoptotic and anti-fibrotic efficacy of exercise training in hypertensive hearts: A systematic review.Frontiers in cardiovascular medicine · 2023Review
- Effect of hypertriglyceridemia on left ventricular global longitudinal strain in patients with coronary heart disease in Jilin Province, China: a cross-sectional study.Frontiers in cardiovascular medicine · 2023Article
- The Management of Hypertensive Emergencies-Is There a "Magical" Prescription for All?Journal of clinical medicine · 2022Review
- Current applications and limitations of European guidelines on blood pressure measurement: implications for clinical practice.Internal and emergency medicine · 2022Review
- Role of strain echocardiography in patients with hypertension.Clinical hypertension · 2022Review
- Cardiac dysfunction in spontaneously hypertensive old rats is associated with a significant decrease of SUR2 expression.Molecular and cellular biochemistry · 2021Article
- Impact of Diabetes on Cardiac Function in Patients with High Blood Pressure.International journal of environmental research and public health · 2021Article
- Myocardial Strain Imaging in Resistant Hypertension.Current hypertension reports · 2021Review
- Development and Psychometric Validation of the Hypertension Beliefs Assessment Tool Among Adult Population in Northwest Ethiopia.Patient preference and adherence · 2021Article
- The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms.Frontiers in medicine · 2021Review
- The additive effects of type 2 diabetes mellitus on left ventricular deformation and myocardial perfusion in essential hypertension: a 3.0 T cardiac magnetic resonance study.Cardiovascular diabetology · 2020Article
- Blood pressure and heart failure.Clinical hypertension · 2020Review
- Conventional and new electrocardiographic criteria for hypertension-mediated cardiac organ damage: A narrative review.Journal of clinical hypertension (Greenwich, Conn.) · 2019Review
- 2018 Korean society of hypertension guidelines for the management of hypertension: part III-hypertension in special situations.Clinical hypertension · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart failure represents a major cause of disease burden worldwide and is expected to further rise in the coming decades. Hypertension is the clinical condition most frequently associated to heart failure.
objectiveTo systematically review the incidence of heart failure compared to coronary heart diseases and stroke in recent hypertension trials.
methodsWe identified 23 trials concluded within the last decade including 193,424 patients with hypertension or at 'high' cardiovascular risk with a predominant presence of hypertensive patients, and reported incidence of major cardiovascular events, including heart failure, coronary heart disease and stroke.
resultsA total of 24 837 major cardiovascular events were recorded in trials performed between 1997 and 2007, of which 7171 (28.9%) were cases of heart failure, 10,223 (41.1%) of coronary heart disease and 7443 (30.0%) of stroke. The rate of heart failure was comparable with that of stroke, accounting for 8.5 and 9.1 events per 1000 patients (P = NS), respectively. Heart failure development was more prevalent in older subjects (>65 years) [odds ratio: 3.08, confidence interval 95% (2.88-3.31); P < 0.0001], in black versus nonblack individuals [odds ratio 1.90, (1.76-2.06); P < 0.0001], in diabetic versus nondiabetic patients [odds ratio 4.91, 95% confidence interval (4.40-5.43); P < 0.0001] and in patients with 'very high' risk versus those with a 'high' risk profile [odds ratio 1.29, 95% confidence interval (1.23-1.36); P < 0.0001].
conclusionOur analysis shows that heart failure development remains a major problem in hypertension. In recent trials on hypertension, the development of heart failure was found comparable with that of stroke: it is more prevalent in older, black, diabetic and 'very high' risk individuals. These findings highlight the relevance of heart failure development in hypertension and support the need for optimizing antihypertensive strategies aimed at preventing the progression to overt heart failure, thus reducing the growing burden of disease associated with hypertension.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.