ArticleMolecular biology of the cell2008
Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
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- Optimization of a novel expression system for recombinant protein production in CHO cells.Scientific reports · 2024Article
- Anti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine.Scientific reports · 2023Article
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- Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity.International journal of molecular sciences · 2021Article
- Anti-Cancer Effects ofMolecules (Basel, Switzerland) · 2020Article
- MicroRNA and mRNA analysis of angiotensin II-induced renal artery endothelial cell dysfunction.Experimental and therapeutic medicine · 2020Article
- Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K/Akt1/GSK-3β signaling pathway in anOncotarget · 2017Article
- Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models.BMC cancer · 2016Article
- Mitochondrial dysfunction and oxidative stress in aging and cancer.Oncotarget · 2016Review
- Autophagy in stem and progenitor cells.Cellular and molecular life sciences : CMLS · 2016Review
- Apaf1 inhibition promotes cell recovery from apoptosis.Protein & cell · 2015Article
- Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth.Cellular and molecular life sciences : CMLS · 2015Article
- Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer.Journal of bioenergetics and biomembranes · 2015Article
- Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability.Carcinogenesis · 2014Article
- The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.Science signaling · 2014Article
- Subclinical carbon monoxide limits apoptosis in the developing brain after isoflurane exposure.Anesthesia and analgesia · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Cytochrome c release from mitochondria promotes apoptosome formation and caspase activation. The question as to whether mitochondrial permeabilization kills cells via a caspase-independent pathway when caspase activation is prevented is still open. Here we report that proneural cells of embryonic origin, when induced to die but rescued by apoptosome inactivation are deprived of cytosolic cytochrome c through proteasomal degradation. We also show that, in this context, those cells keep generating ATP by glycolysis for a long period of time and that they keep their mitochondria in a depolarized state that can be reverted. Moreover, under these conditions, such apoptosome-deficient cells activate a Beclin 1-dependent autophagy pathway to sustain glycolytic-dependent ATP production. Our findings contribute to elucidating what the point-of-no-return in apoptosis is. They also help in clarifying the issue of survival of apoptosome-deficient proneural cells under stress conditions. Unraveling this issue could be highly relevant for pharmacological intervention and for therapies based on neural stem cell transfer in the treatment of neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.