ArticleMolecular endocrinology (Baltimore, Md.)2008
A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta gene.
Article in Molecular endocrinology (Baltimore, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- GnRH pulse frequency is decoded by distinct GαHormones (Athens, Greece) · 2026Article
- Involvement of Pax6 in the transcriptional regulation of gnrh1 in the Asian stinging catfish Heteropneustes fossilis.Fish physiology and biochemistry · 2026Article
- Functional roles of NR4A transcription factors in GnRH regulation of gonadotropin gene expression and secretion in rat primary pituitary cells.The Journal of reproduction and development · 2026Article
- GnRH-driven FTO-mediated RNA mBMC biology · 2024Article
- Article
- Deletion of Gαq/11 or Gαs Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice.Endocrinology · 2022Article
- Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion.Animals : an open access journal from MDPI · 2021Review
- AMP-activated protein kinase activation reduces the transcriptional activity of the murine luteinizing hormone β-subunit gene.The Journal of reproduction and development · 2020Article
- GnRH-A Key Regulator of FSH.Endocrinology · 2019Review
- Molecular regulation of follicle-stimulating hormone synthesis, secretion and action.Journal of molecular endocrinology · 2018Review
- Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression.Molecular and cellular endocrinology · 2018Review
- Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene.The Journal of reproduction and development · 2016Article
- GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER.Molecular endocrinology (Baltimore, Md.) · 2016Article
- GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression.Molecular and cellular endocrinology · 2014Review
- Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes.Molecular endocrinology (Baltimore, Md.) · 2013Article
- A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells.Mathematical biosciences · 2013Article
- GnRH pulse frequency-dependent stimulation of FSHβ transcription is mediated via activation of PKA and CREB.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Phosphorylation of ATF2 and interaction with NFY induces c-Jun in the gonadotrope.Molecular and cellular endocrinology · 2013Article
- G proteins and autocrine signaling differentially regulate gonadotropin subunit expression in pituitary gonadotrope.The Journal of biological chemistry · 2012Article
- Calcineurin mediates the gonadotropin-releasing hormone effect on expression of both subunits of the follicle-stimulating hormone through distinct mechanisms.Molecular and cellular biology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Although FSH plays an essential role in controlling gametogenesis, the biology of FSHbeta transcription remains poorly understood, but is known to involve the complex interplay of multiple endocrine factors including GnRH. We have identified a GnRH-responsive element within the rat FSHbeta promoter containing an E-box and partial cAMP response element site that are bound by the basic helix loop helix transcription factor family members, upstream stimulating factor (USF)-1/USF-2, and the basic leucine zipper member, cAMP response element-binding protein (CREB), respectively. Expression studies with CREB, USF-1/USF-2, and activating protein-1 demonstrated that the USF transcription factors increased basal transcription, an effect not observed if the cognate binding site was mutated. Conversely, expression of a dominant negative CREB mutant or CREB knockdown attenuated induction by GnRH, whereas dominant negative Fos or USF had no effect on the GnRH response. GnRH stimulation specifically induced an increase in phosphorylated CREB occupation of the FSHbeta promoter, leading to the recruitment of CREB-binding protein to enhance gene transcription. In conclusion, a composite element bound by both USF and CREB serves to integrate signals for basal and GnRH-stimulated transcription of the rat FSHbeta gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.