ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Sensory transduction in peripheral nerve axons elicits ectopic action potentials.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Morphological Correlates of TRPV1 Agonist-Induced Activation and Defunctionalization of Nociceptor Neurons.International journal of molecular sciences · 2025Review
- Activity-Dependent Ectopic Spiking in Parvalbumin-Expressing Interneurons of the Neocortex.eNeuro · 2024Article
- Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia.Purinergic signalling · 2023Article
- Carpal tunnel syndrome conservative treatment: a literature review.Postepy psychiatrii neurologii · 2022Review
- Nobel somatosensations and pain.Pflugers Archiv : European journal of physiology · 2022Review
- The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin.Physiological reports · 2022Article
- Potential mechanisms of acupuncture for neuropathic pain based on somatosensory system.Frontiers in neuroscience · 2022Review
- Properties of Thermal Analgesia in a Human Chronic Low Back Pain Model.Journal of pain research · 2020Article
- Synaptic entrainment of ectopic action potential generation in hippocampal pyramidal neurons.The Journal of physiology · 2018Article
- Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation.Seminars in immunopathology · 2018Review
- Acute corneal epithelial debridement unmasks the corneal stromal nerve responses to ocular stimulation in rats: implications for abnormal sensations of the eye.Journal of neurophysiology · 2017Article
- Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain.Scientific reports · 2017Article
- Pulsed 808-nm infrared laser stimulation of the auditory nerve in guinea pig cochlea.Lasers in medical science · 2014Article
- Review
- Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.Progress in neurobiology · 2011Review
- Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review.British journal of pharmacology · 2011Article
- Visceral organ cross-sensitization - an integrated perspective.Autonomic neuroscience : basic & clinical · 2010Review
- Novel wavelengths for laser nerve stimulation.Lasers in surgery and medicine · 2010Article
- Ectopic discharge in Abeta afferents as a source of neuropathic pain.Experimental brain research · 2009Review
- Neuropathic pain: a maladaptive response of the nervous system to damage.Annual review of neuroscience · 2009Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory properties of unmyelinated axons in the isolated rat sciatic nerve have been revealed previously by measuring stimulated neuropeptide release in response to noxious stimuli. In addition, axonal sensitization by inflammatory mediators has been demonstrated and shown to depend on the heat- and proton-activated ion channel transient receptor potential vanilloid receptor-1. It was unclear whether this responsiveness is accompanied by ectopic generation of action potentials, which may play a crucial role in painful neuropathies. We explored this hypothesis using the isolated mouse skin-nerve preparation. This method enabled us to directly compare the sensory properties of axons in the peripheral nerve with their characterized cutaneous terminals in the receptive field using propagated action potentials as an index of axonal activation. Single-fiber recordings from 51 mechanosensitive mouse C-fibers revealed that a majority of the polymodal nociceptors responded with an encoding discharge rate to graded heating of the cutaneous receptive field (n = 38) as well as of the saphenous nerve carrying the fiber under investigation (n = 25; 66%). Axonal heat responses paralleled those of the receptive fields with regard to thresholds and discharge rates (41.5 +/- 4.3 degrees C; 7.7 +/- 9.6 spikes in a 20 s 32-48 degrees C ranged stimulation). In contrast, axonal mechanosensitivity was poor and noxious cold sensitivity more rarely encountered. In conclusion, peripheral nerve axons exhibit sensory transduction capacities similar to their nociceptive terminals in the skin with respect to noxious heat, although not to mechanical and cold sensitivity. This may become a source of ectopic discharge and pain if axonal heat threshold drops to body temperature, as may be the case during inflammation-like processes in peripheral nerves.
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Registered trials
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