ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
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- Spatial Learning and Motor Deficits inExperimental neurobiology · 2019Article
- Sleep deprivation impairs synaptic tagging in mouse hippocampal slices.Neurobiology of learning and memory · 2018Article
- Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Molecular Genetic Strategies in the Study of Corticohippocampal Circuits.Cold Spring Harbor perspectives in biology · 2015Review
- Neuromodulatory signaling in hippocampus-dependent memory retrieval.Hippocampus · 2015Review
- Transiently increasing cAMP levels selectively in hippocampal excitatory neurons during sleep deprivation prevents memory deficits caused by sleep loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Genes and signaling pathways involved in memory enhancement in mutant mice.Molecular brain · 2014Review
- A molecular basis for interactions between sleep and memory.Sleep medicine clinics · 2011Article
- Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins.Neuron · 2010Review
- Investigation of molecular mechanism of chronic pain in the anterior cingulate cortex using genetically engineered mice.Current genomics · 2010Article
- Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The molecular and cellular biology of enhanced cognition.Nature reviews. Neuroscience · 2009Review
- Genetic dissection of neural circuits and behavior in Mus musculus.Advances in genetics · 2009Review
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 3 countries.
Funding
Abstract
Consistent evidence from pharmacological and genetic studies shows that cAMP is a critical modulator of synaptic plasticity and memory formation. However, the potential of the cAMP signaling pathway as a target for memory enhancement remains unclear because of contradictory findings from pharmacological and genetic approaches. To address these issues, we have developed a novel conditional genetic system in mice based on the heterologous expression of an Aplysia octopamine receptor, a G-protein-coupled receptor whose activation by its natural ligand octopamine leads to rapid and transient increases in cAMP. We find that activation of this receptor transgenically expressed in mouse forebrain neurons induces a rapid elevation of hippocampal cAMP levels, facilitates hippocampus synaptic plasticity, and enhances the consolidation and retrieval of fear memory. Our findings clearly demonstrate that acute increases in cAMP levels selectively in neurons facilitate synaptic plasticity and memory, and illustrate the potential of this heterologous system to study cAMP-mediated processes in mammalian systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.