ArticleJournal of neurophysiology2008
Altered pontine taste processing in a rat model of obesity.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Taste Changes after Bariatric Surgery: a Systematic Review.Obesity surgery · 2018Pooled it
- Differential Effects of Maternal High Fat Diet During Pregnancy and Lactation on Taste Preferences in Rats.Nutrients · 2020Article
- The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity.Cellular and molecular life sciences : CMLS · 2020Review
- Differential Effects of Diet and Weight on Taste Responses in Diet-Induced Obese Mice.Obesity (Silver Spring, Md.) · 2020Article
- Taste Responses in the Nucleus of the Solitary Tract of Awake Obese Rats Are Blunted Compared With Those in Lean Rats.Frontiers in integrative neuroscience · 2019Article
- Exercise, Obesity and CNS Control of Metabolic Homeostasis: A Review.Frontiers in physiology · 2018Review
- Diet-induced obesity reduces the responsiveness of the peripheral taste receptor cells.PloS one · 2013Article
- Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice.Journal of neurophysiology · 2012Article
- Gastric bypass surgery alters behavioral and neural taste functions for sweet taste in obese rats.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Altered orosensory sensitivity to oils in CCK-1 receptor deficient rats.Physiology & behavior · 2010Article
- Parabrachial coding of sapid sucrose: relevance to reward and obesity.Annals of the New York Academy of Sciences · 2009Review
- Functional implications for modulating neuropeptide Y gene expression in the dorsomedial hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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2 authors at 1 institution in 1 country.
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Abstract
The increased palatability of modern diet contributes to eating beyond homeostatic need and in turn to the growing prevalence of obesity. How palatability is coded in taste-evoked neural activity and whether this activity differs between obese and lean remains unknown. To investigate this, we used extracellular single-unit recording in the second central gustatory relay, the pontine parabrachial nucleus while stimulating the tongue with various concentrations of sucrose (0.01-1.5 M) in Otsuka Long Evans Tokushima Fatty (OLETF) rats, lacking CCK-1R. The analyses included a total of 179 taste-responsive neurons in age-matched prediabetic, obese OLETF and lean Long Evans Tokushima Otsuka (LETO) controls. Compared with LETO, we found more NaCl-, and fewer sucrose-responsive neurons (67 vs. 47% and 14 vs. 32%), and an overall reduced response magnitude to sucrose in the OLETF rats. Further, in the obese rats there was a rightward shift in sucrose concentration-response functions relative to lean controls with a higher response-threshold (0.37+/-0.05 vs. 0.23+/-0.2 M, P<0.05) and maximal neural response to higher sucrose concentrations (0.96+/-0.07 vs. 0.56+/-0.5 M, P<0.001). These findings demonstrate altered central gustatory processing for sucrose in obese OLETF rat and further support the notion that palatability is encoded in the across neuron pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.