ArticleDevelopment (Cambridge, England)2008
Patterns of cell signaling pathway activation that characterize mammary development.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- An in utero exposure to the synthetic estrogen diethylstilbestrol affects the fat pad composition in post-natal mammary glands.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model.Oncogene · 2024Article
- A common regulatory haplotype doubles lactoferrin concentration in milk.Genetics, selection, evolution : GSE · 2024Article
- Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer.Cancer discovery · 2022Article
- PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.Breast cancer research : BCR · 2022Article
- Mammary epithelial cell transcriptome reveals potential roles of lncRNAs in regulating milk synthesis pathways in Jersey and Kashmiri cattle.BMC genomics · 2022Article
- Low E2F2 activity is associated with high genomic instability and PARPi resistance.Scientific reports · 2020Article
- Psychosocial Stress Exposure Disrupts Mammary Gland Development.Journal of mammary gland biology and neoplasia · 2018Article
- Using gene expression data to direct breast cancer therapy: evidence from a preclinical trial.Journal of molecular medicine (Berlin, Germany) · 2018Review
- Transcription factor compensation during mammary gland development in E2F knockout mice.PloS one · 2018Article
- Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer.Journal of mammary gland biology and neoplasia · 2017Article
- Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- LPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal development.Scientific reports · 2016Article
- Recent artificial selection in U.S. Jersey cattle impacts autozygosity levels of specific genomic regions.BMC genomics · 2015Article
- HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors.Oncogene · 2015Article
- The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer.Molecular and cellular biology · 2014Article
- Article
- Multilayered chromatin analysis reveals E2f, Smad and Zfx as transcriptional regulators of histones.Nature structural & molecular biology · 2013Article
- A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy.Cancer research · 2012Article
- Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.Genome research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previous work has detailed the histological and biochemical changes associated with mammary development and remodeling. We have now made use of gene expression profiling, and in particular of the previously described signatures of cell signaling pathway activation, to explore the events associated with mammary gland development. We find that there is elevated E2F-specific pathway activity prior to lactation and relatively low levels of other important signaling pathways, such as RAS, MYC and SRC. Upon lactation and continuing into the involution phase, these patterns reverse with a dramatic increase in RAS, SRC and MYC pathway activity and a decline in E2F activity. At the end of involution, these patterns return to that of the adult non-lactating mammary gland. The importance of the changes in E2F pathway activity, particularly during the proliferative phase of mammary development, was confirmed through the analysis of mice deficient for various E2F proteins. Taken together, these results reveal a complex pattern of pathway activity in relation to the various phases of mammary gland development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.