ArticleJournal of virology2008
The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and saliva.Investigative ophthalmology & visual science · 2009Trial
- Impact of Latent Virus Infection in the Cornea on Corneal Healing after Small Incision Lenticule Extraction.Microorganisms · 2023Article
- Disease parameters following ocular herpes simplex virus type 1 infection are similar in male and female BALB/C mice.PloS one · 2023Article
- Intranasal drug delivery: opportunities and toxicologic challenges during drug development.Drug delivery and translational research · 2022Review
- How an increase in the copy number of HSV-1 during latency can cause Alzheimer's disease: the viral and cellular dynamics according to the microcompetition model.Journal of neurovirology · 2021Article
- Herpes Simplex Virus Type-1 Infection: Associations with Inflammation and Cognitive Aging in Relation to Schizophrenia.Current topics in behavioral neurosciences · 2020Review
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- Article
- Viral Hypothesis and Antiviral Treatment in Alzheimer's Disease.Current neurology and neuroscience reports · 2018Review
- Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease -conformist, nonconformist, and realistic prospects for AD pathogenesis.Translational neurodegeneration · 2018Review
- Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer's Disease.Frontiers in neurology · 2018Article
- Article
- Corneal edema and keratitis following selective laser trabeculoplasty.American journal of ophthalmology case reports · 2017Article
- Diet-induced obesity prolongs neuroinflammation and recruits CCR2(+) monocytes to the brain following herpes simplex virus (HSV)-1 latency in mice.Brain, behavior, and immunity · 2016Article
- Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways.Antiviral research · 2016Article
- Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis.International journal of ophthalmology · 2016Article
- The Current State of Vaccine Development for Ocular HSV-1 Infection.Expert review of ophthalmology · 2015Article
- Diffusion tensor magnetic resonance imaging of trigeminal nerves in relapsing herpetic keratouveitis.PloS one · 2015Article
- Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.Science translational medicine · 2014Article
- Thyroid hormone-dependent epigenetic suppression of herpes simplex virus-1 gene expression and viral replication in differentiated neuroendocrine cells.Journal of the neurological sciences · 2014Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The purpose of this study was to determine the presence and copy numbers of herpes simplex virus type 1 (HSV-1) DNA in human trigeminal ganglia (TG) with respect to age, gender, and postmortem interval (PMI). Human TG (n = 174, obtained from the Oregon Brain Bank, with data on age, gender, and PMI) were analyzed for HSV-1 DNA copies (HSV-1 DNA polymerase gene) by using real-time PCR. We found that 89.1% (131/147) of subjects and 90.1% (155/174) of TG contained HSV-1 DNA. The copy numbers of HSV-1 DNA in the positives ranged from very high (>10(6)) to very low (5). These data confirm and strengthen our previous findings that subjects were positive for HSV-1 DNA in tears (46/50; 92%) and saliva (47/50; 94%). These TG data and tear and saliva data demonstrated considerable variability in copy numbers of HSV-1 DNA per subject. Statistical analysis showed no significant relationship between gender and copy number, age and copy number, or PMI and copy number for each pair of variables. A factorial analysis of gender, age, and PMI with respect to copy number also showed no statistical significance. This is the first study that provides statistical analysis that documents that the prevalence of HSV-1 DNA in the human TG is not a function of either gender or age.
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