ArticleVirology2008
A model for the dynamic nuclear/nucleolar/cytoplasmic trafficking of the porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein based on live cell imaging.
Article in Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Porcine reproductive and respiratory syndrome virus antagonizes the host restriction factor SHFL to sustain viral programmed ribosomal frameshifting and replication.Journal of virology · 2026Article
- Analysis of the Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Interactome.Journal of proteome research · 2025Article
- Research progress on the N protein of porcine reproductive and respiratory syndrome virus.Frontiers in microbiology · 2024Review
- Identification of peptide domains involved in the subcellular localization of the feline coronavirus 3b protein.The Journal of general virology · 2019Article
- Viruses and the nucleolus: the fatal attraction.Biochimica et biophysica acta · 2014Article
- Overview: Replication of porcine reproductive and respiratory syndrome virus.Journal of microbiology (Seoul, Korea) · 2013Review
- NC-mediated nucleolar localization of retroviral gag proteins.Virus research · 2013Article
- Article
- Biophysical characterisation of the nucleocapsid protein from a highly pathogenic porcine reproductive and respiratory syndrome virus strain.Biochemical and biophysical research communications · 2012Article
- Activation of NF-κB by nucleocapsid protein of the porcine reproductive and respiratory syndrome virus.Virus genes · 2011Article
- Modulation of host cell responses and evasion strategies for porcine reproductive and respiratory syndrome virus.Virus research · 2010Review
- Nucleolar proteomics and viral infection.Proteomics · 2010Review
- Nucleolar targeting: the hub of the matter.EMBO reports · 2009Review
- The lactate dehydrogenase-elevating virus capsid protein is a nuclear-cytoplasmic protein.Archives of virology · 2009Article
- Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus.Virology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, in common with many other positive strand RNA viruses, encodes a nucleocapsid (N) protein which can localise not only to the cytoplasm but also to the nucleolus in virus-infected cells and cells over-expressing N protein. The dynamic trafficking of positive strand RNA virus nucleocapsid proteins and PRRSV N protein in particular between the cytoplasm and nucleolus is unknown. In this study live imaging of permissive and non-permissive cell lines, in conjunction with photo-bleaching (FRAP and FLIP), was used to investigate the trafficking of fluorescent labeled (EGFP) PRRSV-N protein. The data indicated that EGFP-PRRSV-N protein was not permanently sequestered to the nucleolus and had equivalent mobility to cellular nucleolar proteins. Further the nuclear import of N protein appeared to occur faster than nuclear export, which may account for the observed relative distribution of N protein between the cytoplasm and the nucleolus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.