Evidence map›Paper›PMID 18549793›Full record

ArticleImmunity2008

Acid test: lipid antigens get into the groove.

Mitchell Kronenberg, Barbara A Sullivan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. T cells specific for lipid antigens.Immunologic research · 2012
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Mitchell KronenbergLa Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA. mitch@liai.org
Barbara A Sullivan

Funding

Development and Function of NKT CellsR37AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2006 to 2015
$4.9M
Antigen Presentation Pathway by CD1 MoleculesR01AI040617 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KRONENBERG, MITCHELL · 1997 to 2006
$1.6M
6 · The paper itself

Abstract

How do CD1 molecules load lipid antigens? In this issue of Immunity, Relloso et al. (2008) uncover how lysosomal pH targets amino acids in CD1b, causing it to open and attain a conformation more receptive to lipid antigens.

Indexed as

Antigen PresentationAnimalsAntigens, CD1HumansHydrogen-Ion ConcentrationLipidsProtein ConformationAntigens, CD1Lipids

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.