ArticleImmunity2008
Permission to proceed: Jak3 and STAT5 signaling molecules give the green light for T helper 1 cell differentiation.
Article in Immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Risk variants disrupting enhancers of TProceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Ubiquitous Expression ofLife (Basel, Switzerland) · 2025Article
- Transcriptional and epigenetic regulation of T-helper lineage specification.Immunological reviews · 2014Review
- Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis.The Journal of biological chemistry · 2013Article
- Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins.Immunology · 2012Review
- In vitro and in vivo differentiated effector CD8 T cells display divergent histone acetylation patterns within the Ifng locus.Immunology letters · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In this issue of Immunity, Shi et al. (2008) identify a previously unknown requirement in T helper cell differentiation, showing that Jak3 and STAT5 are needed to generate chromatin that is permissive to the activating effects of T-bet.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.