There's more than one way to scale a synapse.

Carlos D Aizenman, Kara G Pratt

Abstract readComment

In one paragraph

Article in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies.International journal of molecular sciences · 2023
Review
Neural Field Continuum Limits and the Structure-Function Partitioning of Cognitive-Emotional Brain Networks.Biology · 2023
Review
TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions.Cells · 2020
Review
Synaptoimmunology - roles in health and disease.Molecular brain · 2017
Review
Intermittent reductions in respiratory neural activity elicit spinal TNF-α-independent, atypical PKC-dependent inactivity-induced phrenic motor facilitation.American journal of physiology. Regulatory, integrative and comparative physiology · 2015
Article
How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014
Review
Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009
Review

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Carlos D AizenmanDepartment of Neuroscience, Brown University, Providence, RI 02912, USA. carlos_aizenman@brown.edu

Kara G Pratt

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TNFalpha has been proposed to underlie synaptic scaling, but the mechanism and functional significance of this remain unclear. In this issue of Neuron, Cingolani et al. demonstrate that TNFalpha can mediate scaling through the regulation of beta3 integrins. Kaneko et al. show that TNFalpha-dependent synaptic scaling plays an important role in visual cortical plasticity.

Indexed as

AnimalsIntegrin beta3Neuronal PlasticitySynapsesTumor Necrosis Factor-alphaVisual CortexIntegrin beta3Tumor Necrosis Factor-alpha

Identifiers

PMID18549775

DOI10.1016/j.neuron.2008.05.017

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.