ArticleBMC molecular biology2008
TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.
Article in BMC molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- The TATA-box binding protein-associated factor TAF12b facilitates the degradation of type B response regulators to negatively regulate cytokinin signaling.Plant communications · 2024Article
- IL-33 stimulates the anticancer activities of eosinophils through extracellular vesicle-driven reprogramming of tumor cells.Journal of experimental & clinical cancer research : CR · 2024Article
- Contributions of methionine to recognition of trimethyllysine in aromatic cage of PHD domains: implications of polarizability, hydrophobicity, and charge on binding.Chemical science · 2021Article
- Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdTCold Spring Harbor molecular case studies · 2020Article
- Article
- Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4.The Journal of biological chemistry · 2018Article
- p53, p63 and p73 in the wonderland ofOncotarget · 2017Review
- The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells.Cancer cell international · 2017Article
- Structural visualization of the p53/RNA polymerase II assembly.Genes & development · 2016Article
- Article
- Discriminating lymphomas and reactive lymphadenopathy in lymph node biopsies by gene expression profiling.BMC medical genomics · 2011Article
- A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.The EMBO journal · 2010Article
- Structures of three distinct activator-TFIID complexes.Genes & development · 2009Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe tumour suppressor protein p53 is a sequence specific DNA-binding transcription regulator, which exerts its versatile roles in genome protection and apoptosis by affecting the expression of a large number of genes. In an attempt to obtain a better understanding of the mechanisms by which p53 transcription function is regulated, we studied p53 interactions.
resultsWe identified BIP2 (Bric-à-brac interacting protein 2), the fly homolog of TAF3, a histone fold and a plant homeodomain containing subunit of TFIID, as an interacting partner of Drosophila melanogaster p53 (Dmp53). We detected physical interaction between the C terminus of Dmp53 and the central region of TAF3 both in yeast two hybrid assays and in vitro. Interestingly, DmTAF3 can also interact with human p53, and mammalian TAF3 can bind to both Dmp53 and human p53. This evolutionarily conserved interaction is functionally significant, since elevated TAF3 expression severely and selectively inhibits transcription activation by p53 in human cell lines, and it decreases the level of the p53 protein as well.
conclusionWe identified TAF3 as an evolutionarily conserved negative regulator of p53 transcription activation function.
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