ArticleMolecular neurobiology
Acetylcholine receptor gamma-subunits mRNA isoforms expressed in denervated rat muscle.
Article in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Effects of aging and Parkinson's disease on motor unit remodeling: influence of resistance exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Defects in Neuromuscular Transmission May Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fetal acetylcholine (ACh) receptor, composed of the alphabetagammadelta subunits, is expressed in fetal, neonatal, and denervated muscle. Single-channel recording has revealed three kinetically distinct classes in neonatal and denervated muscle, suggesting that at least three forms of the gamma-subunit are required. To account for the kinetic classes observed, we compared the messenger ribonucleic acid (mRNA) forms expressed in neonatal and denervated muscle using reverse transcriptase polymerase chain reaction, cloning, and RNAse protection assays. We found five novel forms arising from alternative splicing, which we named gamma5-gamma9. The forms gamma5, gamma6, and gamma7 lack exon 4 and 63-, 89-, and 136 bp of exon 5, respectively. A gamma8 form lacks exons 3 and 4 and 19 bp of exon 5. The last, gamma9, lacks exons 3, 4, and 5. Results indicate that gamma4 predominates in fetal muscle and gamma7 in denervated adult muscle. Some of the gamma-subunit mRNAs found may generate the receptors observed in muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.