Evidence map›Paper›PMID 18548352›Full record

ReviewClinical reviews in allergy & immunology2009

Control of cholangiocyte adaptive responses by visceral hormones and neuropeptides.

Marco Marzioni, Giammarco Fava, Domenico Alvaro, Gianfranco Alpini, Antonio Benedetti

Abstract readReview
In one paragraph

Review in Clinical reviews in allergy & immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Physiology of cholangiocytes.Comprehensive Physiology · 2013
    Review
  8. Hedgehog signaling in the liver.Journal of hepatology · 2011
    Review
  9. Role of sex hormones in the modulation of cholangiocyte function.World journal of gastrointestinal pathophysiology · 2010
    Article
  10. Involvement of cholangiocyte proliferation in biliary fibrosis.World journal of gastrointestinal pathophysiology · 2010
    Article
  11. Cholangiocyte proliferation and liver fibrosis.Expert reviews in molecular medicine · 2009
    Review
  12. Crosstalk of liver, bile ducts and the gut.Clinical reviews in allergy & immunology · 2009
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marco MarzioniDepartment of Gastroenterology, Università Politecnica delle Miarche, Nuovo Polo Didattico, III piano, Via Tronto 10, 60020, Ancona, Italy. m.marzioni@univpm.it
Giammarco Fava
Domenico Alvaro
Gianfranco Alpini
Antonio Benedetti

Funding

Regulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9M
NIDDK NIH HHS DK062975NIDDK NIH HHS R01 DK062975
6 · The paper itself

Abstract

Cholangiocytes, the epithelial cells lining the biliary tree, are the target cells in several liver diseases, termed cholangiopathies. Cholangiopathies are a challenge for clinicians and an enigma for scientists, as the pathogenetic mechanisms by which they develop, and the therapeutic tools for these diseases are still undefined. Several studies demonstrate that many visceral hormones, neuropeptides, and neurotransmitters modulate the adaptive changes of cholangiocytes to chronic cholestatic injury. The aim of this review is to present the recent findings that contributed to clarify the role of visceral hormones and neuropeptides in the regulation of the pathophysiology of cholestasis. These studies helped to shed light on some aspects of cholangiocyte pathophysiology, revealing novel perspectives for the clinical managements of cholangiopathies.

Indexed as

AnimalsApoptosisBiliary TractCholestasisChronic DiseaseEpithelial CellsHumansNeuropeptidesPeptide HormonesNeuropeptidesPeptide Hormones

Identifiers

PMID18548352
PMCPMC2628969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.