ArticleThe review of diabetic studies : RDS2008
SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset.
Article in The review of diabetic studies : RDS, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients.Clinical and experimental immunology · 2015Trial
- Genetic Associations With C-peptide Levels Before Type 1 Diabetes Diagnosis in At-risk Relatives.The Journal of clinical endocrinology and metabolism · 2025Article
- Autoantibodies to Zinc Transporter 8 andJournal of diabetes research · 2022Article
- What has zinc transporter 8 autoimmunity taught us about type 1 diabetes?Diabetologia · 2019Review
- Downregulation of T-Cell Transcription Factors in Adult Latent Autoimmune Diabetes with High-Titer Glutamic Acid Decaroxylase Antibody.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Article
- Importance of Zinc Transporter 8 Autoantibody in the Diagnosis of Type 1 Diabetes in Latin Americans.Scientific reports · 2017Article
- Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus.Journal of diabetes investigation · 2016Review
- Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop.Diabetes care · 2015Article
- Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus.Chinese medical journal · 2015Review
- Heterodimerization, altered subcellular localization, and function of multiple zinc transporters in viable cells using bimolecular fluorescence complementation.The Journal of biological chemistry · 2015Article
- Zinc and the aging brain.Genes & nutrition · 2014Article
- Article
- Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance.The Journal of biological chemistry · 2012Article
- Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases.Diabetologia · 2012Article
- Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells.DNA repair · 2011Article
- German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results.The review of diabetic studies : RDS · 2010Article
- Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation.The review of diabetic studies : RDS · 2010Review
- No association of multiple type 2 diabetes loci with type 1 diabetes.Diabetologia · 2009Article
- Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk.Diabetologia · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It was recently shown that the major allele of the SLC30A8 (zinc transporter 8, ZnT8) single nucleotide polymorphism (SNP) rs13266634 was associated with type 2 diabetes and with reduced insulin secretion in non-diabetic relatives. Because of its role in beta-cell function, we hypothesized that this candidate SNP may confer increased susceptibility for beta-cell destruction in type 1 diabetes. We analyzed SLC30A8 genotypes in 874 patients with type 1 diabetes and 1021 control subjects. No difference in allele and genotype frequencies of the SLC30A8 SNP rs13266634 was found between patients and controls. Analysis with respect to age at type 1 diabetes onset, however, showed that patients with a diabetes onset before age 5 years had an increased prevalence of the cytosine (C) allele (risk allele, 82%) and the homozygous CC genotype (65%) compared to patients who developed type 1 diabetes after age 5 years (67% and 49%; p < 0.01) and compared to controls (69% and 48%; p < 0.03). These data suggest that genetic susceptibility for beta-cell dysfunction in the presence of autoimmunity may lead to accelerated progression and early manifestation of the disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.