ArticleKidney international2008
Association of anemia and erythropoiesis stimulating agents with inflammatory biomarkers in chronic kidney disease.
Article in Kidney international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Effect of paricalcitol vs calcitriol on hemoglobin levels in chronic kidney disease patients: a randomized trial.PloS one · 2015Trial
- Correction of postkidney transplant anemia reduces progression of allograft nephropathy.Journal of the American Society of Nephrology : JASN · 2012Trial
- New-onset anemia and associated risk of ESKD and death in non-dialysis CKD patients: a multicohort observational study.Clinical kidney journal · 2022Article
- Genetic Susceptibility to Acute Kidney Injury.Journal of clinical medicine · 2021Review
- Molecular Aspects and Treatment of Iron Deficiency in the Elderly.International journal of molecular sciences · 2020Review
- Interleukin-6 Contributes to the Development of Anemia in Juvenile CKD.Kidney international reports · 2019Article
- Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 5/6 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Outcomes in patients with chronic kidney disease not on dialysis receiving extended dosing regimens of darbepoetin alfa: long-term results of the EXTEND observational cohort study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Observational
- Effects of Secondary Hyperparathyroidism Treatment on Improvement in Anemia: Results from the MBD-5D Study.PloS one · 2016Article
- A randomized crossover study of single biweekly administration of epoetin-α compared with darbepoetin-α in chronic kidney disease patients not receiving dialysis.Kidney research and clinical practice · 2014Article
- Effect of erythropoietin on primed leucocyte expression profile.Open biology · 2014Article
- Responsiveness to erythropoiesis-stimulating agents in chronic kidney disease: does geography matter?Drugs · 2014Article
- Frequency of TGF- β and IFN- γ genotype as risk factors for acute kidney injury and death in intensive care unit patients.BioMed research international · 2014Article
- Clinical factors and the decision to transfuse chronic dialysis patients.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors.BMC nephrology · 2011Article
- Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease.PloS one · 2010Article
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6 authors at 3 institutions in 1 country.
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Abstract
Inflammatory cytokines are important predictors of cardiovascular mortality especially in patients with chronic kidney disease. Here we explored the relationship of anemia and epoetin treatment to inflammatory cytokine levels in patients with chronic kidney disease. One hundred non-dialysis patients with chronic kidney disease over 18 years of age were evenly split into anemic and non-anemic cohorts. Of the 50 anemic patients, 23 were receiving erythropoiesis stimulating agents treatments. Levels of tumor necrosis factor (TNF)-alpha were found to be significantly higher and serum albumin was significantly lower with trends towards higher interleukin (IL)-6 and IL-8 in anemic compared to non-anemic patients. Further analysis by multiple logistic regression found that anemic patients treated with erythropoiesis stimulating agents had significantly higher odds for the upper two quartiles for IL-6, IL-8 and TNF-alpha compared to non-anemic patients. Our study found that the anemia of chronic kidney disease was associated with up regulation of TNF-alpha, and possibly IL-6 and IL-8 along with increased levels of these proinflammatory cytokines in patients treated with epoetin.
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