Evidence map›Paper›PMID 18547802›Full record

ArticleCurrent opinion in structural biology2008

RNA dynamics: it is about time.

Hashim M Al-Hashimi, Nils G Walter

Abstract read
In one paragraph

Article in Current opinion in structural biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers.

0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

193 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Rho (bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Quantifying MgbioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

133 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hashim M Al-HashimiDepartment of Chemistry and Biophysics, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109-1055, United States. hashimi@umich.edu
Nils G Walter

Funding

U-turn of the Hepatitis Delta Virus RibozymeR01GM062357 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTER, NILS G · 2001 to 2019
$5.8M
Targeting HIV-1 Regulatory RNA ElementsR01AI066975 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AL-HASHIMI, HASHIM M · 2005 to 2014
$2.6M
Real-time Fluorescence Imaging of RNA/Ribosome DynamicsR01GM037006 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORRIS, MICHAEL DAVID · 1986 to 2009
$1.5M
Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPsR01GM081025 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTER, NILS G · 2007 to 2010
$998k
NIAID NIH HHS R01 AI066975NIAID NIH HHS R01 AI066975-01NIGMS NIH HHS GM037006NIGMS NIH HHS GM081025NIGMS NIH HHS R01 GM037006NIGMS NIH HHS R01 GM062357NIGMS NIH HHS R01 GM081025
6 · The paper itself

Abstract

Many recently discovered RNA functions rely on highly complex multistep conformational transitions that occur in response to an array of cellular signals. These dynamics accompany and guide, for example, RNA cotranscriptional folding, ligand sensing and signaling, site-specific catalysis in ribozymes, and the hierarchically ordered assembly of ribonucleoproteins. RNA dynamics are encoded by both the inherent properties of RNA structure, spanning many motional modes with a large range of amplitudes and timescales, and external trigger factors, ranging from proteins, nucleic acids, metal ions, metabolites, and vitamins to temperature and even directional RNA biosynthesis itself. Here, we review recent advances in our understanding of RNA dynamics as highlighted by biophysical tools.

Indexed as

Nucleic Acid ConformationRNATranscription, GeneticRNA

Identifiers

PMID18547802
PMCPMC2580758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.