ArticleNeurobiology of aging2010
Differential effects of COMT on gait and executive control in aging.
Article in Neurobiology of aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Pooled it
- Dual decline in gait and cognition as a high-risk clinical phenotype: differential associations with cerebral amyloid-Frontiers in aging neuroscience · 2026Article
- Nigrostriatal dopaminergic integrity in relation to prefrontal cortex activity and gait performance during dual-task walking in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Data-driven approaches to executive function performance and structure in aging: Integrating person-centered analyses and machine learning risk prediction.Neuropsychology · 2021Article
- Catechol-O-methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults.Journal of the American Geriatrics Society · 2021Article
- Sarcopenia and Neuroscience: Learning to Communicate.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Is impaired dopaminergic function associated with mobility capacity in older adults?GeroScience · 2021Article
- Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a Biracial Cohort of Older Adults.Journal of the American Geriatrics Society · 2021Article
- Genetic polymorphisms for BDNF, COMT, and APOE do not affect gait or ankle motor control in chronic stroke: A preliminary cross-sectional study.Topics in stroke rehabilitation · 2021Article
- Interaction of Catechol-O-methyltransferase ValBrain and behavior · 2020Article
- Influence of Striatal Dopamine, Cerebral Small Vessel Disease, and Other Risk Factors on Age-Related Parkinsonian Motor Signs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Genetic markers of dopaminergic transmission predict performance for older males but not females.Neurobiology of aging · 2018Article
- Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease.Parkinsonism & related disorders · 2018Article
- Article
- Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Catechol-O-Methyltransferase Genotype and Gait Speed Changes over 10 Years in Older Adults.Journal of the American Geriatrics Society · 2017Article
- Article
- Online fronto-cortical control of simple and attention-demanding locomotion in humans.NeuroImage · 2015Article
- At the interface of sensory and motor dysfunctions and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- What can biomarkers tell us about cognition in Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Walking speed is associated with attention and executive control processes subserved by the prefrontal cortex. Because polymorphisms in catechol-O-methyltransferase (COMT) influence these cognitive processes we hypothesized that the same polymorphisms may influence gait velocity. We examined the associations between the Val(158)Met polymorphism in COMT and gait velocity as well as attention and executive function. Participants were 278 non-demented older adults. The results revealed that methionine (Met)/valine (Val) was associated with faster gait velocity. This association can be explained by the putative role of the Val allele in regulating tonic dopamine release in the striatum. In contrast, Met/Met was associated with better attention and executive function. Stratification by gender revealed that the association between COMT genotype and gait was significant only in men. Conversely, the association between COMT genotype and attention and executive function was significant only in women. These findings suggest a differential effect in relating the Val(158)Met polymorphism to gait and to cognitive function while supporting the previously described sexual dimorphism in the phenotypic expressions of COMT.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.