ArticleJournal of neuroimmunology2008
CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome.
Article in Journal of neuroimmunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Increased VH4+JH6+ antibody heavy chain use in plasmablasts from asymptomatic multiple sclerosis patients.Genes and immunity · 2026Article
- Extensive peripheral immunoglobulin repertoire analyses in people with multiple sclerosis reveal disease-specific signatures and distinct treatment effects of disease modifying drugs.Journal of neuroinflammation · 2026Article
- VH2+ Antigen-Experienced B Cells in the Cerebrospinal Fluid Are Expanded and Enriched in Pediatric Anti-NMDA Receptor Encephalitis.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Next Generation Sequencing of Cerebrospinal Fluid B Cell Repertoires in Multiple Sclerosis and Other Neuro-Inflammatory Diseases-A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2021Review
- Impact of B cells to the pathophysiology of multiple sclerosis.Journal of neuroinflammation · 2019Review
- Statistical classifiers for diagnosing disease from immune repertoires: a case study using multiple sclerosis.BMC bioinformatics · 2017Article
- Peripheral blood lymphocytes immunophenotyping predicts disease activity in clinically isolated syndrome patients.BMC neurology · 2017Article
- Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.Acta neuropathologica · 2017Article
- Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants.Acta neuropathologica · 2015Article
- MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing.Gene · 2015Article
- The Ins and Outs of B Cells in Multiple Sclerosis.Frontiers in immunology · 2015Review
- B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.Science translational medicine · 2014Article
- B cells in MS and NMO: pathogenesis and therapy.Seminars in immunopathology · 2014Review
- The antibody genetics of multiple sclerosis: comparing next-generation sequencing to sanger sequencing.Frontiers in neurology · 2014Article
- Cerebrospinal-fluid-derived immunoglobulin G of different multiple sclerosis patients shares mutated sequences in complementarity determining regions.Molecular & cellular proteomics : MCP · 2013Article
- The evidence for a role of B cells in multiple sclerosis.Neurology · 2012Review
- Viruses and multiple sclerosis.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica.Annals of neurology · 2009Article
- Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.Journal of neuroimmunology · 2009Article
- Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid.Annals of neurology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Using FACS and single cell reverse transcriptase polymerase chain reaction, we examined the cerebrospinal fluid (CSF) IgG VH repertoires from 10 subjects with a clinically isolated demyelinating syndrome (CIS). B and plasma cell repertoires from individual subjects showed similar VH family germline usage, nearly identical levels of post-germinal center somatic hypermutation, and significant overlap in their clonal populations. Repertoires from 7 of 10 CIS subjects demonstrated a biased usage of VH4 and/or VH2 family gene segments in their plasma or B cell repertoires. V-regionbias, however, was not observed in the corresponding peripheral blood CD19+ B cell repertoires from 2 CIS subjects or in normal healthy adults. Clinically, subjects with VH4 or VH2 CSF IgG repertoire bias rapidly progressed to definite MS, whereas individuals without repertoire bias did not develop MS after a minimum of 2 years of follow-up (p=0.01).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.