ArticleThe Journal of allergy and clinical immunology2008
Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study.
Article in The Journal of allergy and clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Correlation of High Resolution CT Findings With Lung Function in Adolescents With Perinatally Acquired HIV on Anti-Retroviral Therapy.Pediatric pulmonology · 2025Article
- NK cells in treated HIV-infected children display altered phenotype and function.The Journal of allergy and clinical immunology · 2019Article
- Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques.The Journal of clinical investigation · 2018Article
- Long-term pulmonary complications in perinatally HIV-infected youth.The Journal of allergy and clinical immunology · 2017Article
- Lung Function in South African Adolescents Infected Perinatally with HIV and Treated Long-Term with Antiretroviral Therapy.Annals of the American Thoracic Society · 2017Article
- Bronchiectasis and other chronic lung diseases in adolescents living with HIV.Current opinion in infectious diseases · 2017Review
- Obstructive Lung Diseases in HIV: A Clinical Review and Identification of Key Future Research Needs.Seminars in respiratory and critical care medicine · 2016Review
- HIV-associated obstructive lung diseases: insights and implications for the clinician.The Lancet. Respiratory medicine · 2014Review
- Allergic diseases in subjects under 18 years living with HIV.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014Article
- Immunology of pediatric HIV infection.Immunological reviews · 2013Review
- Human immunodeficiency virus-associated obstructive lung diseases.Clinics in chest medicine · 2013Review
- The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts.PloS one · 2013Article
- Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection.Clinical immunology (Orlando, Fla.) · 2012Article
- HIV and asthma, is there an association?Respiratory medicine · 2012Review
- Asthma diagnosis and airway bronchodilator response in HIV-infected patients.The Journal of allergy and clinical immunology · 2012Article
- High prevalence of asthma in HIV-infected adults: new insights.The Journal of allergy and clinical immunology · 2012Article
- Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents.Clinical immunology (Orlando, Fla.) · 2012Article
- Association between HLA inheritance and asthma medication use in HIV positive children.AIDS (London, England) · 2010Article
- Secondary immunodeficiencies, including HIV infection.The Journal of allergy and clinical immunology · 2010Review
- Advances in basic and clinical immunology in 2008.The Journal of allergy and clinical immunology · 2009Review
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundImmunoreconstitution of HIV(+) patients after treatment with highly active antiretroviral therapy (HAART) appears to provoke inflammatory diseases.
objectiveWe sought to determine whether HIV(+) children receiving HAART (HIV(+) HAART(+)) have a higher incidence of asthma than HIV(+) children not receiving HAART (HIV(+) HAART(-)).
methodsTwo thousand six hundred sixty-four children (193 HIV(+) and 2471 HIV(-) children) born to HIV(+) women were evaluated for the incidence and prevalence of asthma (ie, asthma medication use) and change of CD4(+) T-cell percentage with time.
resultsThe HIV(+) HAART(+) children had higher CD4(+) T-cell percentages, lower CD8(+) T-cell percentages, and lower viral burdens than the HIV(+) HAART(-) children (P < or = .05 to P < or = .01). The cumulative incidence of asthma medication use in HIV(+) HAART(+) children at 13.5 years increased to 33.5% versus 11.5% in HIV(+) HAART(-) children (hazard ratio, 3.34; P = .01) and was equal to that in the HIV(-) children. In children born before the HAART era, the prevalence of asthma medication use for HIV(+) HAART(+) children at 11 years of age was 10.4% versus 3.8% for HIV(+) HAART(-) children (odds ratio, 3.38; P = .02) and was equal to that of the HIV(-) children. The rate of change of CD4(+) T cells around the time of first asthma medication for HIV(+) HAART(+) versus HIV(+) HAART(-) children was 0.81%/y versus -1.43%/y (P = .01).
conclusionThe increased incidence of asthma in HIV(+) HAART(+) children might be driven by immunoreconstitution of CD4(+) T cells.
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