ArticleStructure (London, England : 1993)2008
Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.
Article in Structure (London, England : 1993), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function.Frontiers in immunology · 2024Article
- Integrin Regulators in Neutrophils.Cells · 2022Review
- A database of calculated solution parameters for the AlphaFold predicted protein structures.Scientific reports · 2022Article
- Conformational Equilibrium of Human Platelet Integrin Investigated by Three-Dimensional Electron Cryo-Microscopy.Sub-cellular biochemistry · 2018Review
- Article
- Computing translational diffusion and sedimentation coefficients: an evaluation of experimental data and programs.European biophysics journal : EBJ · 2015Article
- EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane.PloS one · 2013Article
- PROBINGNano LIFE · 2013Article
- Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy.The Journal of biological chemistry · 2011Article
- Multiscale simulations suggest a mechanism for integrin inside-out activation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Integrin structure, activation, and interactions.Cold Spring Harbor perspectives in biology · 2011Review
- Molecular dynamics simulations of forced unbending of integrin α(v)β₃.PLoS computational biology · 2011Article
- Article
- Dynamic regulation of fibrinogen: integrin αIIbβ3 binding.Biochemistry · 2010Article
- Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3.The Journal of biological chemistry · 2010Article
- Focal adhesions are sites of integrin extension.The Journal of cell biology · 2010Article
- The implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analysis suite: enhanced capabilities allow the reliable hydrodynamic modeling of virtually any kind of biomacromolecule.European biophysics journal : EBJ · 2010Article
- Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins.Proteins · 2009Article
- Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.The Journal of cell biology · 2009Article
- The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling.The EMBO journal · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Integrin-dependent adhesion and signaling are regulated by conformational changes whose details remain controversial. Crystallography revealed bent shapes for resting and primed integrin ectodomains, whereas large, ligand-induced rearrangements in other constructs suggested extension, "opening," and tail separation. We have used experimental/computed hydrodynamics to discriminate among different alpha(v)beta(3) and alpha(IIb)beta(3) atomic models built on X-ray, NMR, and EM data. In contrast with X-ray structures and EM maps, hydrodynamics indicate that resting integrins are already extended. Furthermore, the hydrodynamics of an alpha(v)beta(3) ectodomain-fibronectin fragment complex support opening via additional head region conformational changes (hybrid domain swing-out), but without tail separation. Likewise, frictional changes induced by priming agents in full-length alpha(IIb)beta(3) correlate well with the swing-out coupled to a simple transmembrane helix shift in an extended, electron tomography-based model. Extension and immediate tail separation are then uncoupled from head region rearrangements following activation, thus underscoring integrins' delicate, finely tuned plasticity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.