ArticleStructure (London, England : 1993)2008
Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain.
Article in Structure (London, England : 1993), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis.Diabetologia · 2024Article
- The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model.Genesis (New York, N.Y. : 2000) · 2021Review
- Article
- Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.Nature communications · 2020Article
- Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons.Cell · 2020Article
- A dynamically interacting flexible loop assists oligomerisation of the Caenorhabditis elegans centriolar protein SAS-6.Scientific reports · 2019Article
- Latrophilin's Social Protein Network.Frontiers in neuroscience · 2019Review
- Catching Latrophilin With Lasso: A Universal Mechanism for Axonal Attraction and Synapse Formation.Frontiers in neuroscience · 2019Review
- Compatible topologies and parameters for NMR structure determination of carbohydrates by simulated annealing.PloS one · 2017Article
- Super-complexes of adhesion GPCRs and neural guidance receptors.Nature communications · 2016Article
- Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders.Translational neuroscience · 2016Review
- Structural basis of latrophilin-FLRT interaction.Structure (London, England : 1993) · 2015Article
- Ancient interaction between the teneurin C-terminal associated peptides (TCAP) and latrophilin ligand-receptor coupling: a role in behavior.Frontiers in neuroscience · 2015Review
- Adhesion G-protein-coupled receptors: elusive hybrids come of age.Cell communication & adhesion · 2013Review
- Structural analysis of collagen type I interactions with human fibronectin reveals a cooperative binding mode.The Journal of biological chemistry · 2013Article
- The structure of a Streptomyces avermitilis α-L-rhamnosidase reveals a novel carbohydrate-binding module CBM67 within the six-domain arrangement.The Journal of biological chemistry · 2013Article
- A lectin from the mussel Mytilus galloprovincialis has a highly novel primary structure and induces glycan-mediated cytotoxicity of globotriaosylceramide-expressing lymphoma cells.The Journal of biological chemistry · 2012Article
- The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors.Cell reports · 2012Article
- Folding helical proteins in explicit solvent using dihedral-biased tempering.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structural analysis of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) intracellular domain reveals a conserved interaction epitope.The Journal of biological chemistry · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Latrophilin-1 (Lat-1), a target receptor for alpha-Latrotoxin, is a putative G protein-coupled receptor implicated in synaptic function. The extracellular portion of Lat-1 contains a rhamnose binding lectin (RBL)-like domain of unknown structure. RBL domains, first isolated from the eggs of marine species, are also found in the ectodomains of other metazoan transmembrane proteins, including a recently discovered coreceptor of the neuronal axon guidance molecule SLT-1/Slit. Here, we describe a structure of this domain from the mouse Lat-1. RBL adopts a unique alpha/beta fold with long structured loops important for monosaccharide recognition, as shown in the structure of a complex with L-rhamnose. Sequence alignments and mutagenesis show that residues important for carbohydrate binding are often absent in other receptor-attached examples of RBL, including the SLT-1/Slit coreceptor. We postulate that this domain class facilitates direct protein-protein interactions in many transmembrane receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.