ArticleWorld journal of surgical oncology2008
Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome.
Article in World journal of surgical oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Cisplatin Plus Cetuximab Inhibits Cisplatin-Resistant Human Oral Squamous Cell Carcinoma Cell Migration and Proliferation but Does Not Enhance Apoptosis.International journal of molecular sciences · 2021Article
- Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas.BMC veterinary research · 2014Article
- Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition.Oncogene · 2014Article
- Diagnostic impact of promoter methylation and E-cadherin gene and protein expression levels in laryngeal carcinoma.Contemporary oncology (Poznan, Poland) · 2013Article
- Cadherin-catenin complex dissociation in lobular neoplasia of the breast.Breast cancer research and treatment · 2012Article
- Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour).British journal of cancer · 2011Article
- Prognostic significance of claudin expression changes in breast cancer with regional lymph node metastasis.Clinical & experimental metastasis · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe E-cadherin catenin system acts as an invasion suppressor of epithelial malignancies. However, it is debatable whether expression of E-cadherin or catenins is a useful prognostic marker in invasive breast cancer.
methodsWe measured the expression of E-cadherin and catenins (alpha-, beta-, gamma-catenin) in human breast carcinomas using real time quantitative polymerase chain reaction (Q-PCR) and investigated whether the expression levels were associated with known tumour variables or patient survival (median follow-up 72.2 months). RNA from frozen sections of breast tissue (tumour n = 124, background normal tissue n = 33) was reverse transcribed, quantified and analysed by Q-PCR with results expressed as number of copies of transcript/50 ng RNA.
resultsThere was no statistically significant difference in the expression of E-cadherin and catenins (alpha-, beta-, gamma-catenin)in the 33 paired normal background and tumour tissues. The expression of E-cadherin, alpha-, beta-, and gamma-catenin in node positive tumours was similar to node-negative tumours. E-cadherin, alpha-, beta-, and gamma-catenin expression in breast tumours was not related to Nottingham Prognostic Index (NPI). There was no significant difference in the expression of E-cadherin, alpha-, beta-, gamma-catenin between the various TNM stages. None of the molecular markers significantly influenced survival. Lymph node status was the only significant predictor of survival.
conclusionUsing real time quantitative PCR there was no difference in the expression of E-cadherin, alpha-, beta-, gamma-catenin between tumour and normal breast tissue. Furthermore, measurement of expression of these molecules was not of prognostic value in predicting long term outcome of women with breast cancer.
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