Evidence map›Paper›PMID 18547422›Full record

ArticleCritical care (London, England)2008

Intensive care outcomes in bone marrow transplant recipients: a population-based cohort analysis.

Damon C Scales, Deva Thiruchelvam, Alexander Kiss, William J Sibbald, Donald A Redelmeier

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Critical care (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03449953 (Critical Care Outcomes of Patients With Hematologic Malignancy and Hematopoietic Cell Transplantation), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03449953 active not recruitingnot on this mapstarted 2018, after this paper: background citation

Critical Care Outcomes of Patients With Hematologic Malignancy and Hematopoietic Cell Transplantation

TypeobservationalSponsorMount Sinai Hospital, CanadaRan2018 to 2026Enrolled415ConditionsHematologic Malignancy, Stem Cell Transplant
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Damon C ScalesDepartment of Critical Care, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room D108, Toronto, Ontario, Canada, M4N 3M5. damon.scales@utoronto.ca
Deva Thiruchelvam
Alexander Kiss
William J Sibbald
Donald A Redelmeier
Health Sciences Centre · CAInstitute for Clinical Evaluative Sciences · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntensive care unit (ICU) admission for bone marrow transplant recipients immediately following transplantation is an ominous event, yet the survival of these patients with subsequent ICU admissions is unknown. Our objective was to determine the long-term outcome of bone marrow transplant recipients admitted to an ICU during subsequent hospitalizations.

methodsWe conducted a population-based cohort analysis of all adult bone marrow transplant recipients who received subsequent ICU care in Ontario, Canada from 1 January 1992 to 31 March 2002. The primary endpoint was mortality at 1 year.

resultsA total of 2,653 patients received bone marrow transplantation; 504 of which received ICU care during a subsequent hospitalization. Patients receiving any major procedure during their ICU stay had higher 1-year mortality than those patients who received no ICU procedure (87% versus 44%, P < 0.0001). Death rates at 1 year were highest for those receiving mechanical ventilation (87%), pulmonary artery catheterization (91%), or hemodialysis (94%). In combination, the strongest independent predictors of death at 1 year were mechanical ventilation (odds ratio, 7.4; 95% confidence interval, 4.8 to 11.4) and hemodialysis (odds ratio, 8.7; 95% confidence interval, 2.1 to 36.7), yet no combination of procedures uniformly predicted 100% mortality.

conclusionThe prognosis of bone marrow transplant recipients receiving ICU care during subsequent hospitalizations is very poor but should not be considered futile.

Indexed as

AdultBone Marrow TransplantationCatheterization, Swan-GanzCohort StudiesFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleOntarioPatient AdmissionRenal DialysisRespiration, Artificial

Identifiers

PMID18547422
PMCPMC2481474
OpenAlexW2070045700

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.