SynthesisCritical care (London, England)2008
The role of corticosteroids in severe community-acquired pneumonia: a systematic review.
Synthesis in Critical care (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Corticosteroids for pneumonia.The Cochrane database of systematic reviews · 2017Pooled it
- Guidelines for the management of adult lower respiratory tract infections--full version.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2011Guideline
- Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial.Critical care (London, England) · 2011Trial
- How to use biomarkers of infection or sepsis at the bedside: guide to clinicians.Intensive care medicine · 2023Review
- Adjuvant Inhaled Corticosteroids in Community-Acquired Pneumonia: A Review Article.Medical sciences (Basel, Switzerland) · 2021Review
- Article
- Two Cases of Primary Human Parainfluenza Virus 1 Pneumonia in Which Bronchoalveolar Lavage Fluid Yielded Human Parainfluenza Virus 1.Internal medicine (Tokyo, Japan) · 2020Article
- Viral Pneumonia Requiring Differentiation from Acute and Progressive Diffuse Interstitial Lung Diseases.Internal medicine (Tokyo, Japan) · 2019Article
- Inhaled corticosteroids and the increased risk of pneumonia: what's new? A 2015 updated review.Therapeutic advances in respiratory disease · 2016Review
- Glucocorticosteroid in treatment of severe pneumonia.Mediators of inflammation · 2013Review
- Guidelines for diagnosis and management of community- and hospital-acquired pneumonia in adults: Joint ICS/NCCP(I) recommendations.Lung India : official organ of Indian Chest Society · 2012Article
- Defining severe pneumonia.Clinics in chest medicine · 2011Review
- Adjunct corticosteroids in children hospitalized with community-acquired pneumonia.Pediatrics · 2011Article
- Corticosteroids in severe community-acquired pneumonia: the path we choose depends on where we want to get.Critical care (London, England) · 2011Article
- Organizing pneumonia in patients with severe respiratory failure due to novel A (H1N1) influenza.BMJ case reports · 2010Article
- Defining and predicting severe community-acquired pneumonia.Current opinion in infectious diseases · 2010Review
- Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study.Critical care (London, England) · 2010Article
- Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia.Critical care (London, England) · 2010Review
- Bacterial community-acquired pneumonia: risk factors for mortality and supportive therapies.Intensive care medicine · 2009Article
- Corticosteroids for community-acquired pneumonia: time to act!Critical care (London, England) · 2008Article
Corrections and comments
- Commented on byCorticosteroids for community-acquired pneumonia: time to act!2008 · Dosage error in article text
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe purpose of this review was to evaluate the impact of corticosteroids on the outcomes of patients with severe community-acquired pneumonia (CAP).
methodsWe performed a systematic MEDLINE, Cochrane database, and CINAHL search (1966 to November 2007) to identify full-text publications that evaluated the use of corticosteroids in CAP.
resultsAn initial literature search yielded 109 articles, and 105 studies were excluded after the first analysis. We found four studies eligible for analysis. On the basis of their results, the use of corticosteroids as adjunctive therapy in severe CAP should be categorized as a weak recommendation (two studies) and a strong recommendation (two studies) with either low- or moderate-quality evidence. However, no evidence of adverse outcomes or harm is present in the evaluated studies.
conclusionAccording to the GRADE system, available studies do not support the recommendation of corticosteroids as a standard of care for patients with severe CAP. Further randomized controlled trials with this aim should enroll a larger number of severely ill patients. However, in patients needing corticosteroids, it may be reasonable to conclude that corticosteroid administration is safe in patients with severe infections receiving antimicrobial therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.