SynthesisBMC gastroenterology2008
Symptoms of gastroesophageal reflux disease in severely mentally retarded people: a systematic review.
Synthesis in BMC gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Guidelines on diagnosis and management of gastroesophageal reflux disease in infants, children and adolescents: a joint consensus from Italian pediatric societies (SIP and SIGENP) -part I. diagnosis.Italian journal of pediatrics · 2026Guideline
- Investigating pain-related medication use and contribution to polypharmacy in adults with intellectual disabilities: a systematic review.BMC medicine · 2024Pooled it
- Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children.BMC gastroenterology · 2015Pooled it
- Assessing cancer in people with profound and multiple disabilities.BMC cancer · 2023Article
- Evaluation and Management of Respiratory Illness in Children With Cerebral Palsy.Frontiers in pediatrics · 2020Review
- The Medical Care of People With Intellectual Disability.Deutsches Arzteblatt international · 2019Review
- The use of proton pump inhibitors among older adults with intellectual disability: A cross sectional observational study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Pain in Intellectually Disabled Children: Towards Evidence-Based Pharmacotherapy?Paediatric drugs · 2015Article
- Children with cystic fibrosis have prolonged chemical clearance of acid reflux compared to symptomatic children without cystic fibrosis.Digestive diseases and sciences · 2014Article
- Outcomes of pediatric laparoscopic fundoplication: a critical review of the literature.Canadian journal of gastroenterology & hepatology · 2014Review
- Upper gastrointestinal bleeding in children: an 11-year retrospective endoscopic investigation.World journal of pediatrics : WJP · 2012Article
- [Health among persons with intellectual disability in Spain: the European POMONA-II study].Revista de neurologia · 2011Article
- The impact of living arrangements and deinstitutionalisation in the health status of persons with intellectual disability in Europe.Journal of intellectual disability research : JIDR · 2011Article
- Treating acid reflux disease in patients with Down syndrome: pharmacological and physiological approaches.Clinical and experimental gastroenterology · 2011Article
- Obesity and gastroesophageal reflux disease and gastroesophageal reflux symptoms in children.Clinical and experimental gastroenterology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastroesophageal reflux disease (GERD) occurs when stomach acid frequently backs up (or refluxes) into the gullet (or esophagus), and it has serious consequences for the quality of life. Usually this is felt as heartburn. Because severely mentally retarded people usually do not utter complaints of heartburn, it requires a high index of suspicion to discover possible GERD. Therefore it is relevant for care professionals such as nurses to have knowledge of those with a higher risk of GERD and of the possible manifestations of GERD.
methodsUsing a predefined search method, electronic databases were searched for studies relating the presence of symptoms to the presence of GERD. Relevant data were extracted and the methodological quality of the studies assessed. The results of the included studies were synthesized and conclusions about the level of evidence were drawn.
resultsNineteen studies were found relating symptoms to the presence of GERD. Only four were of good methodological quality. The studies were very diverse concerning the studied population, the study method, and the kind of symptoms examined. This makes it difficult to synthesize the results of the studies. There is evidence that patients with cerebral palsy, patients using anticonvulsive drugs, and those with an IQ lower than 35 more frequently have GERD. There is also evidence that vomiting, rumination and hematemesis are associated with a higher risk of the presence of GERD, whereas there is no clear scientific evidence that particular behavior symptoms are indicative for GERD.
conclusionThe possible manifestations of GERD are many and varied. A guideline will be made for care professionals to aid systematic observation of possible manifestations of GERD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.