ArticleBMC infectious diseases2008
Molecular epidemiology of pneumococci obtained from Gambian children aged 2-29 months with invasive pneumococcal disease during a trial of a 9-valent pneumococcal conjugate vaccine.
Article in BMC infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Molecular Epidemiology ofInternational journal of molecular sciences · 2025Pooled it
- Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010Pooled it
- Trial
- Molecular epidemiology of Streptococcus pneumoniae isolates causing invasive and noninvasive infection in Ethiopia.Scientific reports · 2024Article
- Clinical Features and Outcomes of Streptococcus pneumoniae Meningitis in Children: A Retrospective Analysis of 26 Cases in China.Neuropediatrics · 2022Article
- Article
- Construction of a pneumolysin deficient mutant in streptococcus pneumoniae serotype 1 strain 519/43 and phenotypic characterisation.Microbial pathogenesis · 2020Article
- Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013.BMC infectious diseases · 2018Article
- A Population-Based Descriptive Atlas of Invasive Pneumococcal Strains Recovered Within the U.S. During 2015-2016.Frontiers in microbiology · 2018Article
- Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia.The Journal of infectious diseases · 2017Article
- Pre-vaccine serotype composition within a lineage signposts its serotype replacement - a carriage study over 7 years following pneumococcal conjugate vaccine use in the UK.Microbial genomics · 2017Article
- Impact of pneumococcal conjugate vaccines on pneumococcal meningitis cases in France between 2001 and 2014: a time series analysis.BMC medicine · 2016Article
- Associations between nasopharyngeal carriage of Group B Streptococcus and other respiratory pathogens during early infancy.BMC microbiology · 2016Article
- Population structure, epidemiology and antibiotic resistance patterns of Streptococcus pneumoniae serotype 5: prior to PCV-13 vaccine introduction in Eastern Gambia.BMC infectious diseases · 2016Article
- Serotypes and Clonal Diversity of Streptococcus pneumoniae Causing Invasive Disease in the Era of PCV13 in Catalonia, Spain.PloS one · 2016Article
- Dynamics of serotype 14 Streptococcus pneumoniae population causing acute respiratory infections among children in China (1997-2012).BMC infectious diseases · 2015Article
- Comparison of a Real-Time Multiplex PCR and Sequetyping Assay for Pneumococcal Serotyping.PloS one · 2015Article
- Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention.Vaccines · 2014Review
- Article
- Detection of Streptococcus pneumoniae from Different Types of Nasopharyngeal Swabs in Children.PloS one · 2013Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe study describes the molecular epidemiology of Streptococcus pneumoniae causing invasive disease in Gambian children
methodsOne hundred and thirty-two S. pneumoniae isolates were recovered from children aged 2-29 months during the course of a pneumococcal conjugate vaccine trial conducted in The Gambia of which 131 were characterized by serotyping, antibiotic susceptibility, BOX-PCR and MLST.
resultsTwenty-nine different serotypes were identified; serotypes 14, 19A, 12F, 5, 23F, and 1 were common and accounted for 58.3% of all serotypes overall. MLST analysis showed 72 sequence types (STs) of which 46 are novel. eBURST analysis using the stringent 6/7 identical loci definition, grouped the isolates into 17 clonal complexes and 32 singletons. The population structure of the 8 serotype 1 isolates obtained from 4 vaccinated and 2 unvaccinated children were the same (ST 618) except that one (ST3336) of the isolates from an unvaccinated child had a novel ST which is a single locus variant of ST 618.
conclusionWe provide the first background data on the genetic structure of S. pneumoniae causing IPD prior to PC7V use in The Gambia. This data will be important for assessing the impact of PC7V in post-vaccine surveillance from The Gambia.
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